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Pentavalent Antimony-Mannan Conjugate Therapy of Experimental Visceral Leishmaniasis
William L. Roberts
William L. Roberts
Department of Pathology, University of Mississippi Medical Center, Department of Medicine, Cornell University Medical Center, Department of Laboratory Medicine, Yale University School of Medicine, Jackson, Mississippi
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June Hariprashad
June Hariprashad
Department of Pathology, University of Mississippi Medical Center, Department of Medicine, Cornell University Medical Center, Department of Laboratory Medicine, Yale University School of Medicine, Jackson, Mississippi
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Petrie M. Rainey
Petrie M. Rainey
Department of Pathology, University of Mississippi Medical Center, Department of Medicine, Cornell University Medical Center, Department of Laboratory Medicine, Yale University School of Medicine, Jackson, Mississippi
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Henry W. Murray
Henry W. Murray
Department of Pathology, University of Mississippi Medical Center, Department of Medicine, Cornell University Medical Center, Department of Laboratory Medicine, Yale University School of Medicine, Jackson, Mississippi
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Pentavalent antimony-mannan (Sb[V]-mannan) was 10-fold more potent than sodium stibogluconate in a murine model of visceral leishmaniasis. Liver antimony concentrations were six-fold higher after Sb[V]-mannan therapy compared with a dose of sodium stibogluconate that was equipotent in reducing liver parasite burdens. Murine toxicity of Sb[V]-mannan was variable, with a 50% lethal dose (LD50) for one preparation that was well above the concentration that killed 90% of the parasites, and for another preparation was only modestly higher than the concentration that killed 90% of the parasites.
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| Past two years | Past Year | Past 30 Days | |
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