Murine typhus is reported for the first time on the Isthmus of Panama.
The epidemiological study of the cases diagnosed in the present outbreak of murine typhus showed that the focal point of the infection was the storeroom of one of the patients where were found dead rats shortly before the first human case had been diagnosed.
The study of the clinical form of the disease as observed in this outbreak of murine typhus showed that it reproduced, in every aspect, the clinical findings reported in well known text-books.
The author is indebted to Dr. H. C. Clark, Director of the Gorgas Memorial Laboratory, for his suggestions and support in the development of this work.