Atabrine is fungicidal in vitro at concentrations of 25 to 50 mgm. per cent and fungistatic at 3 to 25 mgm. per cent for C. neoformans. Toxic reactions are obtained with much lower plasma or tissue concentrations. Atabrine is, therefore, of little therapeutic value in cryptococcus infections.
From the Department of Pathology, Duke University School of Medicine, Durham, North Carolina.