Numerous observers have reported the treatment of macrocytic anemias with folic acid with the return of the blood to normal. Several (1–6) have found that the macrocytic anaemia of sprue was similarly improved. But so far, no one has reported the effect of folic acid in the maintenance of sprue over many months. For this reason, the fact that five milligrams of folic acid by mouth daily has been sufficient to maintain an old case of sprue in continued health for over one year, should be recorded.
Case History. Diarrhoea commenced in 1924, twelve years after two periods of service in the Philippines. At first the diarrhoea was caused by acids like stewed tomatoes, and could be controlled by a rigid diet, but during a third tour in the Philippines in 1925–1928, the diarrhoea of a watery character became continuous, and following an episode of sore mouth which lasted only one week, the diagnosis of sprue was made.