Experimental Chemotherapy of Amebiasis

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  • Division of Pharmacology and Experimental Therapeutics and the Tropical Diseases Laboratory, University of California Medical School, San Francisco

Summary

  1. (1)The pathogenesis of amebiasis is discussed.
  2. (2)Comparative amebacidal tests in vitro and in vivo have been made, utilizing improved appraisal technics.
  3. (3)The development of an essentially synthetic medium may lead to a more rational approach to the chemotherapy of this disease.
  4. (4)The mechanisms of anti-amebic action have been demonstrated for two of the various chemical types available.
  5. (5)Three trivalent arsenicals (two containing sulfur) have proved of value in trials in macaques, and one has been effective in initial trials in man.

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