The Adaptation of a Cane Rat (Zygodontomys) to the Laboratory and its Susceptibility to the Virus of Yellow Fever

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The Villavicencio cane rat has been found to be well adapted to laboratory culture and manipulation.

The virus of yellow fever seems to grow readily in the brain tissue of this animal, but only about half of the animals are killed. Virus was successfully maintained for twelve serial passes and showed some signs of adaptation in that the rat mortality became successively higher and the incubation period shorter.

Circulating virus was not recovered after subcutaneous or intraperitoneal inoculation, but many animals showed circulating antibodies after such inoculation as well as after intracerebral inoculation as shown by the intracerebral protection test in white mice.