The Laboratory Diagnosis of Endemic Typhus and Rocky Mountain Spotted Fever with Special Reference to Cross-Immunity Tests

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  • P. A. Surgeon, United States Public Health Service


There are certain criteria for the identification of an unknown strain of virus as one of endemic typhus or spotted fever.

Satisfactory cross-immunity tests must be obtained before one can state definitely whether or not an unknown virus is one of spotted fever or typhus. In performing cross-immunity tests precautions must be taken to rule out secondary infections and non-specific immunity.