| Past two years | Past Year | Past 30 Days | |
|---|---|---|---|
| Abstract Views | 0 | 0 | 0 |
| Full Text Views | 24349 | 24349 | 24277 |
| PDF Downloads | 189 | 189 | 158 |
Urogenital Schistosomiasis Is Associated with an Increased Risk of Plasmodium falciparum Infection in Burkina Faso
Mireille Ouedraogo
Mireille Ouedraogo
Department of Translational Research in Medicine and Surgery, University of Pisa, Pisa, Italy;
Department of Public Health and Infectious Diseases, University of Rome La Sapienza, Rome, Italy;
Centre National de Recherche et Formation sur le Paludisme, Ouagadougou, Burkina Faso;
Search for other papers by Mireille Ouedraogo in
Current site
Google Scholar
PubMed
Department of Public Health and Infectious Diseases, University of Rome La Sapienza, Rome, Italy;
Centre National de Recherche et Formation sur le Paludisme, Ouagadougou, Burkina Faso;
Search for other papers by Mireille Ouedraogo in
Current site
Google Scholar
PubMed
Pytsje T. Hoekstra
Pytsje T. Hoekstra
Leiden University Center for Infectious Diseases, Leiden University Medical Centre, Leiden, The Netherlands;
Search for other papers by Pytsje T. Hoekstra in
Current site
Google Scholar
PubMed
Search for other papers by Pytsje T. Hoekstra in
Current site
Google Scholar
PubMed
Youssouf Kabore
Youssouf Kabore
Centre National de Recherche et Formation sur le Paludisme, Ouagadougou, Burkina Faso;
Search for other papers by Youssouf Kabore in
Current site
Google Scholar
PubMed
Search for other papers by Youssouf Kabore in
Current site
Google Scholar
PubMed
Issa Nebie
Issa Nebie
Centre National de Recherche et Formation sur le Paludisme, Ouagadougou, Burkina Faso;
Search for other papers by Issa Nebie in
Current site
Google Scholar
PubMed
Search for other papers by Issa Nebie in
Current site
Google Scholar
PubMed
Stan Hilt
Stan Hilt
Leiden University Center for Infectious Diseases, Leiden University Medical Centre, Leiden, The Netherlands;
Search for other papers by Stan Hilt in
Current site
Google Scholar
PubMed
Search for other papers by Stan Hilt in
Current site
Google Scholar
PubMed
Govert J. van Dam
Govert J. van Dam
Leiden University Center for Infectious Diseases, Leiden University Medical Centre, Leiden, The Netherlands;
Search for other papers by Govert J. van Dam in
Current site
Google Scholar
PubMed
Search for other papers by Govert J. van Dam in
Current site
Google Scholar
PubMed
Paul L. A. M. Corstjens
Paul L. A. M. Corstjens
Department of Cell & Chemical Biology, Leiden University Medical Center, Leiden, The Netherlands
Search for other papers by Paul L. A. M. Corstjens in
Current site
Google Scholar
PubMed
Search for other papers by Paul L. A. M. Corstjens in
Current site
Google Scholar
PubMed
Fabrizio Bruschi
Fabrizio Bruschi
Department of Translational Research in Medicine and Surgery, University of Pisa, Pisa, Italy;
Search for other papers by Fabrizio Bruschi in
Current site
Google Scholar
PubMed
Search for other papers by Fabrizio Bruschi in
Current site
Google Scholar
PubMed
David Modiano
David Modiano
Department of Public Health and Infectious Diseases, University of Rome La Sapienza, Rome, Italy;
Search for other papers by David Modiano in
Current site
Google Scholar
PubMed
Search for other papers by David Modiano in
Current site
Google Scholar
PubMed
Valentina D. Mangano
valentina.mangano@unipi.it
Valentina D. Mangano
Department of Translational Research in Medicine and Surgery, University of Pisa, Pisa, Italy;
Search for other papers by Valentina D. Mangano in
Current site
Google Scholar
PubMed
Search for other papers by Valentina D. Mangano in
Current site
Google Scholar
PubMed
There is significant overlap in the global distribution of malaria and neglected tropical diseases, with the largest health burden in Sub-Saharan Africa, where areas are co-endemic for malaria and schistosomiasis, soil-transmitted helminths, or lymphatic filariasis. Some studies suggest that helminth infections may increase susceptibility to malaria, but evidence is limited. This study investigated the association between urogenital schistosomiasis and the risk of Plasmodium falciparum (P. falciparum) parasitemia in rural Burkina Faso. A cohort of 424 subjects participated in five cross-sectional malaria surveys. Active Schistosoma hematobium infection was diagnosed at baseline using plasma circulating anodic antigen detection, whereas P. falciparum infection was diagnosed at each survey via blood smear microscopy. Longitudinal analysis assessed the association between baseline urogenital schistosomiasis and P. falciparum parasitemia over time, adjusting for sex, age, village, ethnicity, and hemoglobin genotype. Subjects with active urogenital schistosomiasis had a ∼ 25% increase in the cumulative incidence of P. falciparum infection (incidence rate ratio [IRR] = 1.26; 95% CI = 1.08–1.46; P = 0.004), as well as a nonsignificant trend toward higher parasite density (exponential of the β coefficient [Expβ] = 1.12; 95% CI = 0.96–1.31; P = 0.133) and higher odds of infection over five surveys (odds ratio [OR] = 1.79; 95% CI = 0.89–3.59; P = 0.104). Higher intensity of schistosomiasis increased the cumulative incidence of P. falciparum (IRR = 1.12; 95% CI = 1.05–1.19; P = 0.001) and parasite density (Expβ = 1.08; 95% CI = 1.01–1.15; P = 0.026), and a trend toward increased odds of infection was also observed (OR = 1.28; 95% CI = 0.91–1.80; P = 0.159). This study provides longitudinal evidence that urogenital schistosomiasis is associated with an increased risk of P. falciparum parasitaemia, highlighting the need for integrated control strategies for both diseases, particularly in school-aged children and adolescents.
Author Notes
Financial support: This study was supported by a research grant from Sapienza University of Rome (Fondi di Ateneo) to David Modiano and by funds from the PhD School in Microbiology, Infectious Diseases, and Public Health, Sapienza University of Rome, to M. Ouedraogo.
Disclosures: Study subjects or their guardians provided written informed consent for participation. The original malaria epidemiological study received approval from the ethical committee of the Ministry of Health of Burkina Faso (2007–048). The use of archived plasma samples for schistosomiasis research received additional approval from the ethical committee of the Ministry of Health and Public Hygiene of Burkina Faso (2022-05-15).
Authors’ contributions: M. Ouedraogo., P. T. Hoekstra., and S. Hilt conducted the experiments. Y. Kabore. and I. Nebie. coordinated the cross-sectional survey. G. J. van Dam, P. L. A. M. Corstjens, F. Bruschi, D. Modiano, and V. D. Mangano designed experiments and contributed experimental resources. D. Modiano and V. D. Mangano designed the study. V. D. Mangano performed the data analyses and wrote the manuscript. All authors revised and approved the final version of the manuscript.
Current contact information: Mireille Ouedraogo, Youssouf Kabore, and Issa Nebie, Centre National de Recherche et Formation sur le Paludisme, Ouagadougou, Burkina Faso, E-mails: omireille@ymail.com, kabyouf@yahoo.fr, and i.ouedraogo@gras.bf. Pytsje T. Hoekstra, Stan Hilt, and Govert J. van Dam, Leiden University Center for Infectious Diseases, Leiden University Medical Centre, Leiden, The Netherlands, E-mails: p.t.hoekstra-mevius@lumc.nl, s.t.hilt@lumc.nl, and g.j.van_dam@lumc.nl. Paul L. A. M. Corstjens, Department of Cell & Chemical Biology, Leiden University Medical Center, Leiden, The Netherlands, E-mail: p.l.a.m.cortjens@lumc.nl. Fabrizio Bruschi and Valentina D. Mangano, Department of Translational Research in Medicine and Surgery, University of Pisa, Pisa, Italy, E-mails: fabrizio.bruschi@unipi.it and valentina.mangano@unipi.it. David Modiano, Department of Public Health and Infectious Diseases, University of Rome La Sapienza, Rome, Italy, E-mail: david.modiano@uniroma1.it.
| Past two years | Past Year | Past 30 Days | |
|---|---|---|---|
| Abstract Views | 0 | 0 | 0 |
| Full Text Views | 24349 | 24349 | 24277 |
| PDF Downloads | 189 | 189 | 158 |