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Cytokine Production in Response to Soluble Leishmania Aethiopica Antigen by Whole Blood Cells from Patients with Different Clinical Presentations of Cutaneous Leishmaniasis
Bizuayehu Gashaw
Bizuayehu Gashaw
Amhara Public Health Institute, Bahir Dar, Ethiopia;
Department of Biology, College of Science, Bahir Dar University, Bahir Dar, Ethiopia;
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Department of Biology, College of Science, Bahir Dar University, Bahir Dar, Ethiopia;
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Endalew Yizengaw
Endalew Yizengaw
Amhara Public Health Institute, Bahir Dar, Ethiopia;
Department of Medical Laboratory Science, College of Medicine and Health Sciences, Bahir Dar University, Bahir Dar, Ethiopia;
Institute of Biotechnology, Bahir Dar University, Bahir Dar, Ethiopia;
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Department of Medical Laboratory Science, College of Medicine and Health Sciences, Bahir Dar University, Bahir Dar, Ethiopia;
Institute of Biotechnology, Bahir Dar University, Bahir Dar, Ethiopia;
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Edward Cruz Cervera
Edward Cruz Cervera
Department of Infectious Disease, Imperial College London, London, United Kingdom;
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Endalkachew Nibret
Endalkachew Nibret
Department of Biology, College of Science, Bahir Dar University, Bahir Dar, Ethiopia;
Institute of Biotechnology, Bahir Dar University, Bahir Dar, Ethiopia;
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Institute of Biotechnology, Bahir Dar University, Bahir Dar, Ethiopia;
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Dessalegn Tamiru
Dessalegn Tamiru
Nefas Mewcha Hospital, Lay Gayint, Ethiopia;
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Ingrid Müller
Ingrid Müller
Department of Infectious Disease, Imperial College London, London, United Kingdom;
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James A. Cotton
James A. Cotton
School of Biodiversity, One Health and Veterinary Medicine, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom
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Yegnasew Takele
Yegnasew Takele
Department of Infectious Disease, Imperial College London, London, United Kingdom;
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Pascale Kropf
p.kropf@imperial.ac.uk
Pascale Kropf
Department of Infectious Disease, Imperial College London, London, United Kingdom;
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Cutaneous leishmaniasis (CL), a parasitic disease caused by Leishmania aethiopica, is a major health problem in Ethiopia. It presents mostly as three different clinical forms: localized CL characterized by small lesions that ulcerate; diffuse CL defined by multiple nonulcerating nodules; and mucocutaneous leishmaniasis, where the mucosa of the nose or the mouth is affected. The mechanisms resulting in the development of these different clinical presentation are still poorly understood. Here, we recruited a cohort of CL patients presenting with different forms of CL in northwest Ethiopia as well as cohort of healthy nonendemic controls. We assessed the capacity of whole blood cells from these cohorts to produce cytokines in response to soluble L. aethiopica antigen and compared these levels between the different clinical presentations of CL and healthy nonendemic controls. Our results show that the levels of antigen-specific cytokines produced by whole blood cells from CL patients were higher as compared with controls. However, these cytokine levels were similar among the different clinical presentations. In conclusion, the results of our study indicate that variations in clinical manifestations of CL are not associated with differences in antigen-specific cytokine profiles.
Author Notes
Financial support: This research was jointly funded by the
Disclosures: This study was approved by the Research and Ethical Review Committee of the College of Science, Bahir Dar University (RCSVD 002/2011 EC), the National Research Ethics Review Committee of the Ministry of Science and Higher Education of Ethiopia (MoSHE/RD/14.1/10112/2020), and the Imperial College Research Ethics Committee (ICREC 18IC4593). Informed written consent was obtained from each participant.
Current contact information: Bizuayehu Gashaw and Endalew Yizengaw, Amhara Public Health Institute and Bahir Dar University, Bahr Dar, Ethiopia, E-mails: itisbizuayehu@gmail.com and endalew02@gmail.com. Edward Cruz Cervera, Ingrid Müller, and Pascale Kropf, Imperial College London, London, United Kingdom, E-mails: edward.cruz-cervera15@imperial.ac.uk, i.muller@imperal.ac.uk, and p.kropf@imperial.ac.uk. Endalkachew Nibret, Bahir Dar University, Bahir Dar, Ethiopia, E-mail: endtg2002@yahoo.com. Dessalegn Tamiru, Nefas Mewcha Hospital, Lay Gayint, Ethiopia, E-mail: dessalegntamiru8@gmail.com. James A. Cotton, University of Glasgow, Glasgow, United Kingdom, E-mail: james.cotton@glasgow.ac.uk. Yegnasew Takele, King’s College London, London, United Kingdom, E-mail: yegnasew.teferi14@imperial.ac.uk.
| Past two years | Past Year | Past 30 Days | |
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| Full Text Views | 504 | 504 | 386 |
| PDF Downloads | 175 | 175 | 61 |