Invasive Eye Infection Caused by Trichoderma Harzianum

Fei Han Department of Clinical Laboratory, Chongqing University Three Gorges Hospital, Chongqing, China;

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Jiaogui Ou Department of Ophthalmology, Chongqing University Three Gorges Hospital, Chongqing, China

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Na Huang Department of Clinical Laboratory, Chongqing University Three Gorges Hospital, Chongqing, China;

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Trichoderma is a widely distributed thermophilic fungus that grows on moist soil, fallen leaves, and rotten wood. It plays an important role in agricultural production, food processing, and soil. However, some forms of Trichoderma can infect humans. Aggressive infections are more common in immunocompromised patients, with manifestations ranging from focal to disseminated infections. Here, we report a case of an invasive eye infection in China. The patient, a healthy 64-year-old man, was inadvertently struck by a puncture vine, injuring his eye and resulting in reduced visual acuity, lacrimation, and redness in the right eye. Upon admission, he was diagnosed with right eye perforation injury, right eye iris damage, right eye vitreous opacity, and right eye infection. After completion of the relevant auxiliary examinations, the diagnosis was confirmed by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry and metagenomic next-generation sequencing, and the patient responded to antifungal therapy.

Author Notes

Authors’ contributions: F. Han and J. Ou collected the data and analyzed data, F. Han and N. Huang wrote the paper, and N. Huang supervised the research and edited the manuscript.

Current contact information: Fei Han and Na Huang, Department of Clinical Laboratory, Chongqing University Three Gorges Hospital, Chongqing, China, E-mails: cdsxjyk@163.com and cqwshn@163.com. Jiaogui Ou, Department of Ophthalmology, Chongqing University Three Gorges Hospital, Chongqing, China, E-mail: 670272429@qq.com.

Address correspondence to Na Huang, Department of Clinical Laboratory, Chongqing University Three Gorges Hospital, Xincheng St. 165., Chongqing City 404100, China. E-mail: cqwshn@163.com
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