| Past two years | Past Year | Past 30 Days | |
|---|---|---|---|
| Abstract Views | 0 | 0 | 0 |
| Full Text Views | 163 | 163 | 73 |
| PDF Downloads | 158 | 158 | 78 |
Analysis of Clinical and Laboratory Profiles of Patients Hospitalized with Hemorrhagic Fever with Renal Syndrome in Southwestern South Korea
Ma Eum Park
Ma Eum Park
School of Medicine, Chosun University, Dong-gu, Gwangju, South Korea;
Search for other papers by Ma Eum Park in
Current site
Google Scholar
PubMed
Search for other papers by Ma Eum Park in
Current site
Google Scholar
PubMed
Da Young Kim
Da Young Kim
Department of Internal Medicine, College of Medicine, Chosun University, Gwangju, South Korea;
Search for other papers by Da Young Kim in
Current site
Google Scholar
PubMed
Search for other papers by Da Young Kim in
Current site
Google Scholar
PubMed
Jun-Won Seo
Jun-Won Seo
Department of Internal Medicine, College of Medicine, Chosun University, Gwangju, South Korea;
Search for other papers by Jun-Won Seo in
Current site
Google Scholar
PubMed
Search for other papers by Jun-Won Seo in
Current site
Google Scholar
PubMed
Na Ra Yun
Na Ra Yun
Department of Internal Medicine, College of Medicine, Chosun University, Gwangju, South Korea;
Search for other papers by Na Ra Yun in
Current site
Google Scholar
PubMed
Search for other papers by Na Ra Yun in
Current site
Google Scholar
PubMed
You Mi Lee
You Mi Lee
Department of Premedical Science, College of Medicine, Chosun University, Gwangju, South Korea
Search for other papers by You Mi Lee in
Current site
Google Scholar
PubMed
Search for other papers by You Mi Lee in
Current site
Google Scholar
PubMed
Choon Mee Kim
Choon Mee Kim
Department of Premedical Science, College of Medicine, Chosun University, Gwangju, South Korea
Search for other papers by Choon Mee Kim in
Current site
Google Scholar
PubMed
Search for other papers by Choon Mee Kim in
Current site
Google Scholar
PubMed
Dong-Min Kim
Dong-Min Kim
Department of Internal Medicine, College of Medicine, Chosun University, Gwangju, South Korea;
Search for other papers by Dong-Min Kim in
Current site
Google Scholar
PubMed
Search for other papers by Dong-Min Kim in
Current site
Google Scholar
PubMed
Hemorrhagic fever with renal syndrome (HFRS) is caused by hantaviruses. Data of 34 patients with HFRS hospitalized at Chosun University Hospital, South Korea, between 2010 and 2021 were retrospectively analyzed. Nested reverse transcription polymerase chain reaction (RT-nPCR) targeting the L segment of hantavirus and sequencing were used for diagnosis. Most cases occurred in men and during the months of October through December. Common symptoms were fever, chills, gastrointestinal symptoms, and myalgia. The common laboratory abnormalities were thrombocytopenia, proteinuria, and elevated levels of serum creatinine, aspartate transaminase, alanine transaminase, and lactate dehydrogenase. Approximately 91.2% of patients had the Hantaan virus with a new genotype cluster, whereas 8.8% had the Seoul virus. Seropositivity based on IgM titer >1:32 on admission was noted in 20.6%, and a 4-fold increase in IgG titer of 1:512 was observed in 11.8%. This study demonstrated that RT-nPCR targeting the L segment of hantaviruses is a more reliable diagnostic method compared to serological testing.
Author Notes
Financial support: This study was supported by research fund from
Disclosures: The authors declare no potential conflicts of interest concerning the research, authorship, or publication of this article. This study was approved by the Ethics in Human Research Committee of Chosun University Hospital (IRB no. 2013-10-001-018), Gwangju, South Korea.
Current contact information: Ma Eum Park, School of Medicine, Chosun University, Dong-gu, Gwangju, South Korea, E-mail:idofmaum@gmail.com; Da Young Kim, Jun-Won Seo, Na Ra Yun, and Dong-Min Kim, Department of Internal Medicine, College of Medicine, Chosun University, Gwangju, South Korea, E-mails: dayz02@hanmail.net, kaist-105@daum.net, shine@chosun.ac.kr, and drongkim@chosun.ac.kr; You Mi Lee and Choon Mee Kim, Department of Premedical Science College of Medicine, Chosun University, Gwangju, South Korea, E-mails: moksha1001@hanmail.net and choonmee@chosun.ac.kr.
| Past two years | Past Year | Past 30 Days | |
|---|---|---|---|
| Abstract Views | 0 | 0 | 0 |
| Full Text Views | 163 | 163 | 73 |
| PDF Downloads | 158 | 158 | 78 |