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Systematic Review and Meta-Analysis of Female Reproductive Health Following Ebola Virus Disease
Madison Drogy
Madison Drogy
School of Public Health and Tropical Medicine, Tulane University Newcomb–Tulane College, New Orleans, Louisiana;
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Celia Glezer
Celia Glezer
School of Public Health and Tropical Medicine, Tulane University Newcomb–Tulane College, New Orleans, Louisiana;
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Emily Engel
Emily Engel
Department of Pediatrics, Section of Pediatric Infectious Diseases, School of Medicine, Tulane University, New Orleans, Louisiana;
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Nell Bond
Nell Bond
Department of Immunology and Microbiology, School of Medicine, Tulane University, New Orleans, Louisiana;
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Keith Pickett
Keith Pickett
Rudolph Matas Library of the Health Sciences, Tulane University, New Orleans, Louisiana;
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Jeffrey Shaffer
Jeffrey Shaffer
Department of Biostatistics and Data Science, School of Public Health and Tropical Medicine, Tulane University, New Orleans, Louisiana;
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John Schieffelin
John Schieffelin
Department of Pediatrics, Section of Pediatric Infectious Diseases, School of Medicine, Tulane University, New Orleans, Louisiana;
Department of Medicine, Section of Infectious Diseases, School of Medicine, Tulane University, New Orleans, Louisiana
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Department of Medicine, Section of Infectious Diseases, School of Medicine, Tulane University, New Orleans, Louisiana
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Crystal Zheng
czheng5@tulane.edu
Crystal Zheng
Department of Medicine, Section of Infectious Diseases, School of Medicine, Tulane University, New Orleans, Louisiana
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The viral hemorrhagic fevers Lassa fever (LF) and Ebola virus disease (EVD) have been documented to cause long-term health problems in survivors. Limited studies have noted the presence of adverse reproductive health outcomes, including menstrual irregularities and pregnancy loss, after recovery from infection. The objective of this systematic review and meta-analysis is to summarize existing knowledge surrounding reproductive health in female survivors of LF and EVD. Literature was gathered from PubMed, Embase, Ovid Medline, Cumulative Index of Nursing and Allied Health (CINAHL) Complete, Web of Science, and Global Health databases and subsequently reviewed in Covidence. Included studies described at least one reproductive health outcome in women after recovery from EVD or LF. Thirteen studies were identified in the systematic review, all of which only discussed reproductive health in EVD survivors. No studies of reproductive health among survivors of LF were identified. The included studies were conducted in Guinea, Sierra Leone, and Liberia, and they reported irregular menstruation, pregnancy loss, decreased libido, pelvic inflammatory disease, sexual dysfunction, female reproductive odor, and genital problems/infections among survivors. In a meta-analysis of nine studies, 14.0% of female EVD survivors experienced any adverse reproductive health outcome. However, there was significant heterogeneity among the included studies. This study highlights the health problems faced by female EVD survivors and underscores the need for more research surrounding the effects of viral hemorrhagic fevers on women’s health.
Author Notes
Financial support: This project was supported by the
Current contact information: Madison Drogy and Celia Glezer, Newcomb–Tulane College, New Orleans, LA, E-mails: maddydrogy@gmail.com and cglezer@tulane.edu. Emily Engel, Nell Bond, John Schieffelin, and Crystal Zheng, Tulane University School of Medicine, New Orleans, LA, E-mails: eengel@tulane.edu, nbond@tulane.edu, jschieff@tulane.edu, and czheng5@tulane.edu. Keith Pickett, Rudolph Matas Library of the Health Sciences, New Orleans, LA, E-mail: kpicket1@tulane.edu. Jeffrey Shaffer, School of Tropical Medicine and Hygiene, Tulane University, New Orleans, LA, E-mail: jshaffer@tulane.edu.
| Past two years | Past Year | Past 30 Days | |
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| Full Text Views | 196 | 196 | 89 |
| PDF Downloads | 173 | 173 | 86 |