Spatiotemporal Heterogeneity of Zika Virus Transmission in Indonesia: Serosurveillance Data from a Pediatric Population

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  • 1 Eijkman Institute for Molecular Biology, Jakarta, Indonesia;
  • 2 UNICEF Indonesia, Jakarta, Indonesia;
  • 3 Faculty of Medicine and Cipto Mangunkusumo Hospital, Universitas Indonesia, Jakarta, Indonesia;
  • 4 Ministry of Health of the Republic of Indonesia, Jakarta, Indonesia;
  • 5 Sanofi Pasteur, Lyon, Rhône-Alpes, France;
  • 6 Centers for Disease Control and Prevention, Atlanta, Georgia

The presence of Zika virus (ZIKV) in Indonesia has been recognized since the 1970s, but its transmission dynamics there have been poorly understood. To understand more fully the geographic distribution and burden of ZIKV disease, we performed retrospective serological tests on specimens collected from asymptomatic children age 5 to 9 years old living at 30 sites in 14 provinces. Of 870 serum samples tested, 9.2% were found to be positive for anti-ZIKV antibodies, as confirmed by plaque reduction neutralization assays. This was the same overall prevalence reported previously for 1- to 4-year-old children collected at the same sites at the same time. Together with geographic differences in seroprevalence between the age groups, these data suggest that, although ZIKV might be endemic in Indonesia, its occurrence has been focal and episodic.

Author Notes

Address correspondence to R. Tedjo Sasmono, Eijkman Institute for Molecular Biology, Dengue Laboratory, Jl. Diponegoro 69, Jakarta, Indonesia 10430. E-mail: sasmono@eijkman.go.id

Disclaimer: The contents and conclusions of this report are those of the authors and do not necessarily represent the position of the U.S. Centers for Disease Control and Prevention.

Financial support: This work was supported by the Ministry of Research, Technology, and Higher Education of the Republic of Indonesia, the United Nations Children’s Fund, and the U.S. Centers for Disease Control and Prevention.

Authors’ addresses: R. Tedjo Sasmono, Edison Johar, Benediktus Yohan, Chairin Nisa Ma’roef, Amin Soebandrio, and Khin Saw Aye Myint, Eijkman Institute for Molecular Biology, Jakarta, Indonesia, E-mails: sasmono@eijkman.go.id, edisonjohar@eijkman.go.id, yohan@eijkman.go.id, nami@eijkman.go.id, aminsoebandrio@eijkman.go.id, and khinsawying@hotmail.com. Paul Pronyk, UNICEF Indonesia, Jakarta, Indonesia, E-mail: ppronyk@unicef.org. Sri Rezeki Hadinegoro, Faculty of Medicine and Cipto Mangunkusumo Hospital, Universitas Indonesia, Jakarta, Indonesia, E-mail: shadinegoro46@gmail.com. Elizabeth Jane Soepardi, Ministry of Health of the Republic of Indonesia, Jakarta, Indonesia, E-mail: ejanesoepardi@gmail.com. Alain Bouckenooghe, Sanofi Pasteur, Lyon, Rhône-Alpes, France, E-mail: alain_bouckenooghe@merck.com. William A. Hawley, Ronald Rosenberg, and Ann M. Powers, Centers for Disease Control and Prevention, Atlanta, GA, E-mails: byh0@cdc.gov, dcx7@cdc.gov, and akp7@cdc.gov.

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