We would like to thank the following people who have contributed to the project: Communicable Diseases Division of MOH for the epidemiological data of dengue cases, staff of Environmental Public Health Operations involved in mosquito larval surveys and operations, Lam Sai Gek and the Entomological Taxonomy team for identification of mosquito larval samples, EHI Diagnostics for identifying the serotypes of the dengue cases, and the Applied Entomology team for gravitrap surveillance.
WHO, 2016. Dengue Fact Sheet: Vector Borne and Neglected Tropical Disease Control, Data and Statistics. Geneva, Switzerland: World Health Organisation.
Goh KT, Ng SK, Chan YC, Lim SJ, Chua EC, 1987. Epidemiological aspects of an outbreak of dengue fever/dengue haemorrhagic fever in Singapore. Southeast Asian J Trop Med Public Health 18: 295–302.
Koh BK, Ng LC, Kita Y, Tang CS, Ang LW, Wong KY, James L, Goh KT, 2008. The 2005 dengue epidemic in Singapore: epidemiology, prevention and control. Ann Acad Med Singapore 37: 538–645.
Hapuarachchi HC 2016. Epidemic resurgence of dengue fever in Singapore in 2013–2014: a virological and entomological perspective. BMC Infect Dis 16: 300.
Leake C, Goh K, 1998. Dengue in Singapore. Singapore: Institute of Environmental Epidemiology, Ministry of Environment.
Reiter P, Goh K, 1998. Dengue in Singapore. Singapore: Institute of Environmental Epidemiology, Ministry of Environment.
Lai Y-L, Chung Y-K, Tan H-C, Yap H-F, Yap G, Ooi E-E, Ng L-C, 2007. Cost-effective real-time reverse transcriptase PCR (RT-PCR) to screen for dengue virus followed by rapid single-tube multiplex RT-PCR for serotyping of the virus. J Clin Microbiol 45: 935–941.
Pok K-Y, Lai Y-L, Sng J, Ng L-C, 2010. Evaluation of nonstructural 1 antigen assays for the diagnosis and surveillance of dengue in Singapore. Vector Borne Zoonotic Dis 10: 1009–1016.
Lanciotti RS, Calisher CH, Gubler DJ, Chang G-J, Vorndam AV, 1992. Rapid detection and typing of dengue viruses from clinical samples by using reverse transcriptase-polymerase chain reaction. J Clin Microbiol 30: 545–551.
Koo C, Kaur S, Teh Z-Y, Xu H, Nasir A, Lai Y-L, Khan E, Ng L-C, Hapuarachchi HC, 2016. Genetic variability in probe binding regions explains false negative results of a molecular assay for the detection of dengue virus. Vector Borne Zoonotic Dis 16: 489–495.
Lee C, Vythilingam I, Chong C-S, Razak MAA, Tan C-H, Liew C, Pok K-Y, Ng L-C, 2013. Gravitraps for management of dengue clusters in Singapore. Am J Trop Med Hyg 88: 888–892.
Chung Y, Lam‐Phua S, Chua Y, Yatiman R, 2001. Evaluation of biological and chemical insecticide mixture against Aedes aegypti larvae and adults by thermal fogging in Singapore. Med Vet Entomol 15: 321–327.
Singstats, 2016. Population Trends 2016. Republic of Singapore: Department of Statistics, Ministry of Trade and Industry.
R Development Core Team, 2008. R: A Language and Environment for Statistical Computing. Vienna, Austria: R Foundation for Statistical Computing.
Shi Y 2016. Three-month real-time dengue forecast models: an early warning system for outbreak alerts and policy decision support in Singapore. Environ Health Perspect 124: 1369–1375.
ESRI, 2011. ArcGIS Desktop: Release 10. Redlands, CA: Environmental Systems Research Institute.
Ng LC, Lai YL, Cheng C, Barkham T, 2007. Spatial and temporal distribution of dengue serotypes in Singapore. Ministry of Health Singapore. ENB 33: 1–3.
Tang L, 2016. High number of dengue cases expected this year. Todayonline. Available at: mwww.todayonline.com/singapore/dengue-cases-year-be-high-masagos. Accessed March 22, 2018.
Low S-L, Lam S, Wong W-Y, Teo D, Ng L-C, Tan L-K, 2015. Dengue seroprevalence of healthy adults in Singapore: serosurvey among blood donors, 2009. Am J Trop Med Hyg 93: 40–45.
Frentiu FD, Zakir T, Walker T, Popovici J, Pyke AT, van den Hurk A, McGraw EA, O’Neill SL, 2014. Limited dengue virus replication in field-collected Aedes aegypti mosquitoes infected with Wolbachia. PLoS Negl Trop Dis 8: e2688.
Capeding MR CYD14 Study Group, 2014. Clinical efficacy and safety of a novel tetravalent dengue vaccine in healthy children in Asia: a phase 3, randomised, observer-masked, placebo-controlled trial. Lancet 384: 1358–1365.
Messina JP, Brady OJ, Scott TW, Zou C, Pigott DM, Duda KA, Bhatt S, Katzelnick L, Howes RE, Battle KE, 2014. Global spread of dengue virus types: mapping the 70 year history. Trends Microbiol 22: 138–146.
Suwandono A 2006. Four dengue virus serotypes found circulating during an outbreak of dengue fever and dengue haemorrhagic fever in Jakarta, Indonesia, during 2004. Trans R Soc Trop Med Hyg 100: 855–862.
Ng L-C, Chem YK, Koo C, Mudin RNB, Amin FM, Lee K-S, Kheong CC, 2015. 2013 dengue outbreaks in Singapore and Malaysia caused by different viral strains. Am J Trop Med Hyg 92: 1150–1155.
Buddhari D 2014. Dengue virus neutralizing antibody levels associated with protection from infection in Thai cluster studies. PLoS Negl Trop Dis 8: e3230.
McArthur MA, Sztein MB, Edelman R, 2013. Dengue vaccines: recent developments, ongoing challenges and current candidates. Expert Rev Vaccines 12: 933–953.
Moi ML, Takasaki T, Kurane I, 2016. Human antibody response to dengue virus: implications for dengue vaccine design. Trop Med Health 44: 1.
Soo K-M, Khalid B, Ching S-M, Chee H-Y, 2016. Meta-analysis of dengue severity during infection by different dengue virus serotypes in primary and secondary infections. PLoS One 11: e0154760.
Fried JR, Gibbons RV, Kalayanarooj S, Thomas SJ, Srikiatkhachorn A, Yoon I-K, Jarman RG, Green S, Rothman AL, Cummings DA, 2010. Serotype-specific differences in the risk of dengue hemorrhagic fever: an analysis of data collected in Bangkok, Thailand from 1994 to 2006. PLoS Negl Trop Dis 4: e617.
Thomas L 2008. Influence of the dengue serotype, previous dengue infection, and plasma viral load on clinical presentation and outcome during a dengue-2 and dengue-4 co-epidemic. Am J Trop Med Hyg 78: 990–998.
Clapham H 2015. Epidemiology of infant dengue cases illuminates serotype-specificity in the interaction between immunity and disease, and changes in transmission dynamics. PLoS Negl Trop Dis 9: e0004262.
Yew YW, Ye T, Ang LW, Ng LC, Yap G, James L, Chew SK, Goh KT, 2009. Seroepidemiology of dengue virus infection among adults in Singapore. Ann Acad Med Singapore 38: 667–675.
Ang L, Cutter J, James L, Goh K, 2015. Seroepidemiology of dengue virus infection in the adult population in tropical Singapore. Epidemiol Infect 143: 1585–1593.
Table 2. Residents Households by Type of Dwellin, 2000-2017. Available at: http//www.singstat.gov.sg/statistics/browse-by-theme/household-income-tables. Accessed March 22, 2018.
Singstats, 2015. Population Trends 2016. Key Demographic Indicators, 1970-2016. Republic of Singapore: Department of Statistics, Ministry of Trade and Industry.
Hang VT 2009. Diagnostic accuracy of NS1 ELISA and lateral flow rapid tests for dengue sensitivity, specificity and relationship to viraemia and antibody responses. PLoS Negl Trop Dis 3: e360.
Tricou V, Vu HT, Quynh NV, Nguyen CV, Tran HT, Farrar J, Wills B, Simmons CP, 2010. Comparison of two dengue NS1 rapid tests for sensitivity, specificity and relationship to viraemia and antibody responses. BMC Infect Dis 10: 142.
Chaterji S, Allen JC Jr., Chow A, Leo Y-S, Ooi E-E, 2011. Evaluation of the NS1 rapid test and the WHO dengue classification schemes for use as bedside diagnosis of acute dengue fever in adults. Am J Trop Med Hyg 84: 224–228.