The findings and conclusions in this report are those of the authors and do not necessarily represent the official position of the Centers for Disease Control and Prevention. We thank DVBD staff members Jason Velez for cell culture support and Sean Masters and John Liddell for their excellent contributions to animal husbandry and animal care needs throughout this study. We thank IDPB staff members Heather Hayes and Amanda Lewis for histology and immunohistochemistry support.
Schuler-Faccini L 2016. Possible association between Zika virus infection and microcephaly—Brazil, 2015. MMWRMorb Mortal Wkly Rep 65: 59–62.
Ladhani SN, O’Connor C, Kirkbride H, Brooks T, Morgan D, 2016. Outbreak of Zika virus disease in the Americas and the association with microcephaly, congenital malformations and Guillain-Barre syndrome. Arch Dis Child 101: 600–602.
Oehler E, Watrin L, Larre P, Leparc-Goffart I, Lastere S, Valour F, Baudouin L, Mallet H, Musso D, Ghawche F, 2014. Zika virus infection complicated by Guillain-Barre syndrome–case report, French Polynesia, December 2013. Euro Surveill 19.
Roze B 2016. Zika virus detection in urine from patients with Guillain-Barre syndrome on Martinique, January 2016. Euro Surveill 21: 30154.
Rossi SL, Tesh RB, Azar SR, Muruato AE, Hanley KA, Auguste AJ, Langsjoen RM, Paessler S, Vasilakis N, Weaver SC, 2016. Characterization of a novel murine model to study Zika virus. Am J Trop Med Hyg 94: 1362–1369.
Lazear HM, Govero J, Smith AM, Platt DJ, Fernandez E, Miner JJ, Diamond MS, 2016. A mouse model of Zika virus pathogenesis. Cell Host Microbe 19: 720–730.
Boorman JP, Porterfield JS, 1956. A simple technique for infection of mosquitoes with viruses; transmission of Zika virus. Trans R Soc Trop Med Hyg 50: 238–242.
Forster JI, Koglsberger S, Trefois C, Boyd O, Baumuratov AS, Buck L, Balling R, Antony PM, 2016. Characterization of differentiated SH-SY5Y as neuronal screening model reveals increased oxidative vulnerability. J Biomol Screen 21: 496–509.
Weger-Lucarelli J 2017. Development and characterization of recombinant virus generated from a new world Zika virus infectious clone. J Virol 91. Erratum in: J Virol 2017.
Duggal NK, Ritter JM, Pestorius SE, Zaki SR, Davis BS, Chang GJ, Bowen RA, Brault AC, 2017. Frequent Zika virus sexual transmission and prolonged viral RNA shedding in an immunodeficient mouse model. Cell Rep 18: 1751–1760.
Vermillion MS, Lei J, Shabi Y, Baxter VK, Crilly NP, McLane M, Griffin DE, Pekosz A, Klein SL, Burd I, 2017. Intrauterine Zika virus infection of pregnant immunocompetent mice models transplacental transmission and adverse perinatal outcomes. Nat Commun 8: 14575.
Smith DR 2017. Neuropathogenesis of Zika virus in a highly susceptible immunocompetent mouse model after antibody blockade of type I interferon. PLoS Negl Trop Dis 11: e0005296.
Zhu Z, Chan JF, Tee KM, Choi GK, Lau SK, Woo PC, Tse H, Yuen KY, 2016. Comparative genomic analysis of pre-epidemic and epidemic Zika virus strains for virological factors potentially associated with the rapidly expanding epidemic. Emerg Microbes Infect 5: e22.
Lee E, Pavy M, Young N, Freeman C, Lobigs M, 2006. Antiviral effect of the heparan sulfate mimetic, PI-88, against dengue and encephalitic flaviviruses. Antiviral Res 69: 31–38.
Shan C 2016. An infectious cDNA clone of Zika virus to study viral virulence, mosquito transmission, and antiviral inhibitors. Cell Host Microbe 19: 891–900.
Tsetsarkin KA, Kenney H, Chen R, Liu G, Manukyan H, Whitehead SS, Laassri M, Chumakov K, Pletnev AG, 2016. A full-length infectious cDNA clone of Zika virus from the 2015 epidemic in Brazil as a genetic platform for studies of virus-host interactions and vaccine development. MBio 7.
Kumar A, Hou S, Airo AM, Limonta D, Mancinelli V, Branton W, Power C, Hobman TC, 2016. Zika virus inhibits type-I interferon production and downstream signaling. EMBO Rep 17: 1766–1775.