We extend a special thanks and sincere gratitude to the children and legal guardians who participated in this study, the Christianville Foundation Schools, the local medical staff, and Kaylee Sills; without whom this study would not have been possible. We would also like to acknowledge Access Bio, Inc., for donation of the newly developed CareStart G6PD Biosensor Analyzer for independent evaluation by our research team in this field trial.
World Health Organization, 2015. World Malaria Report. Geneva, Switzerland: WHO. Available at: http://www.who.int/malaria/publications/world-malaria-report-2015/report/en/. Accessed December 8, 2016.
Mikolajczak SA et al.., 2015. Plasmodium vivax liver stage development and hypnozoite persistence in human liver-chimeric mice. Cell Host Microbe 17: 526–553.
Galappaththy GNL, Tharyan P, Kirubakaran R, 2013. Primaquine for preventing relapse in people with Plasmodium vivax malaria treated with chloroquine. Cochrane Database Syst Rev 10: CD004389.
Luzzatto L, Metha A, Vulliamy T, 2001. Glucose-6-phosphate dehydrogenase deficiency. Scriver CR, Beaudet AL, Sly WS, eds. The Metabolic and Molecular Bases of Inherited Disease, 9th edition. Columbus, OH: McGraw-Hill, 4517–4553.
Beutler E, Duparc S, 2007. Glucose-6-phosphate dehydrogenase deficiency and antimalarial drug development. Am J Trop Med Hyg 77: 779–789.
World Health Organization, 2015. Point-of-care G6PD testing to support safe use of primaquine for the treatment of vivax malaria. Geneva, Switzerland: WHO. Available at: http://www.who.int/malaria/mpac/mpac-march2015-erg-g6pd.pdf. Accessed November 10, 2016.
Osorio L et al.., 2015. Performance of binaxNOW G6PD deficiency point-of-care diagnostic in P. vivax-infected subjects. Am J Trop Med Hyg 92: 22–27.
Kim S et al.., 2011. Performance of the CareStart G6PD deficiency screening test, a point-of-care diagnostic for primaquine therapy screening. PLoS One 6: e28357.
Access Bio, Inc. Manufacturer Information and Instruction for the Operation of the CareStartTM G6PD Biosensor Analyzer. Available at: http://www.accessbio.net/eng/products/products03.asp. Accessed January 1, 2017.
World Health Organization, 1989. Glucose-6-phosphate dehydrogenase deficiency. WHO Working Group. Bull World Health Organ 67: 601–611.
Carter TE, Maloy H, von Fricken ME, St Victor Y, Romain JR, Okech BA, 2014. Glucose-6-phosphate dehydrogenase deficiency A-variant in febrile patients in Haiti. Am J Trop Med Hyg 91: 412–414.
Tishkoff SA et al.., 2001. Haplotype diversity and linkage disequilibrium at human G6PD: recent origin of alleles that confer malarial resistance. Science 293: 455–462.
Weppelmann TA, Carter TE, Chen Z, von Fricken ME, Victor YS, Existe A, Okech BA, 2013. High frequency of the erythroid silent Duffy antigen genotype and lack of Plasmodium vivax infections in Haiti. Malar J 12: 30.
Weppelmann TA, von Fricken ME, Lam B, Telisma T, Existe A, Lemoine JF, Larkin J III, Okech BA, 2016. Sparse serological evidence of Plasmodium vivax transmission in the Ouest and Sud-Est departments of Haiti. Acta Trop 162: 27–34.
von Fricken ME, Weppelmann TA, Lam B, Eaton WT, Schick L, Masse R, Beau De Rochars MV, Existe A, Larkin J III, Okech BA, 2014. Age-specific malaria seroprevalence rates: a cross-sectional analysis of malaria transmission in the Ouest and Sud-Est departments of Haiti. Malar J 13: 361.
von Fricken ME, Weppelmann TA, Eaton WT, Alam MT, Carter TE, Schick L, Masse R, Romain JR, Okech BA, 2014. Prevalence of glucose-6-phosphate dehydrogenase (G6PD) deficiency in the Ouest and Sud-Est departments of Haiti. Acta Trop 135: 62–66.
von Fricken ME, Weppelmann TA, Eaton WT, Masse R, Beau de Rochars MV, Okech BA, 2014. Performance of the CareStart glucose-6-phosphate dehydrogenase (G6PD) rapid diagnostic test in Gressier, Haiti. Am J Trop Med Hyg 91: 77–80.
Domingo GJ et al.., 2013. G6PD testing in support of treatment and elimination of malaria: recommendations for evaluation of G6PD tests. Malar J 12: 391.
Luzzatto L, Seneca E, 2013. G6PD deficiency: a classic example of pharmacogenetics with on-going clinical implications. Brit J Haem 164: 469–480.