Stability of Primaquine Diphosphate under Various Conditions

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  • U. S. Department of Health, Education, and Welfare, Public Health Service, National Institutes of Health, National Institute of Allergy and Infectious Diseases, Laboratory of Parasits Chemotherapy, Bethesda, Maryland


When primaquine diphosphate was subjected to conditions simulating those ordinarily occurring in the preparation of food, it was found to be unstable. Spectrophotometric analysis indicated a destruction of from 5% to 94% depending upon the conditions of heating. However, when the heated samples were tested against Plasmodium gallinaceum in young chicks, all activity was absent except in the sample boiled in water for 24 hours and in this instance the activity was of a very low order. These findings exclude the use of primaquine as a salt additive in malaria eradication programs.

Author Notes

Present address: Laboratory of Biochemical Pharmacology, Joseph E. Seagram and Sons, Inc., Scientific Department, Cranbury, New Jersey.