• View in gallery

    The patient has hypopigmented papules and plaques scattered over the face, most concentrated peri-orally and on the cheeks, common areas of involvement for post-kala-azar dermal leishmaniasis (PKDL). The patient consented to having his picture published in the journal.

  • View in gallery

    Hypopigmented papules are seen on the patient's back. The lesions are roughly symmetrical, a common characteristic of post-kala-azar dermal leishmaniasis (PKDL), and are painless and non- pruritic.

  • View in gallery

    Hypopigmented papules on the abdomen.

  • View in gallery

    The patient has hypopigmented papules and plaques on both forearms. The absence of sensorineural changes helps to distinguish post-kala-azar dermal leishmaniasis (PKDL) from leprosy, which commonly presents with hypopigmented macules or patches associated with hypoesthesia or anesthesia, and neural thickening.

  • 1.

    Rahman KM, Islam S, Rahman MW, Kenah E, Chowdhury MG, Zahid MM, Maguire J, Rahman M, Haque R, Luby SP, Bern C, 2010. Rising incidence of post kala-azar dermal leishmaniasis in a population-based study in Bangladesh. Clin Infect Dis 50: 7376.

    • Search Google Scholar
    • Export Citation
  • 2.

    Saha S, Mondal S, Ravindran R, Bhowmick S, Modak D, Mallick S, Rahman M, Kar S, Goswami R, Gaha SK, Pramanik N, Saha B, Ali N, 2007. IL-10- and TGF-beta-mediated susceptibility in kala-azar and post-kala-azar dermal leishmaniasis: the significance of amphotericin B in the control of Leishmania donovani infection in India. J Immunol 179: 55925603.

    • Search Google Scholar
    • Export Citation

 

 

 

 

Post-Kala-Azar Dermal Leishmaniasis in Mymensingh, Bangladesh

View More View Less
  • Children's Hospital and Research Center Oakland, Oakland, California; ICDDR,B, Dhaka, Bangladesh; Division of Parasitic Diseases and Malaria, Center for Global Health, Centers for Disease Control and Prevention, Atlanta, Georgia

A 50-year-old man from Mymensingh district, Bangladesh, presented with a 3-month history of non-pruritic, painless hypopigmented papules, and plaques, beginning on the face and subsequently spreading to the forearms, torso, and legs (Figures 14) Fifteen months before the onset of skin lesions, the patient had visceral leishmaniasis (kala-azar), successfully treated with 30 intramuscular injections of sodium stibogluconate (SSG). Polymerase chain reaction showed Leishmania donovani DNA in a buffy coat specimen.

Figure 1.
Figure 1.

The patient has hypopigmented papules and plaques scattered over the face, most concentrated peri-orally and on the cheeks, common areas of involvement for post-kala-azar dermal leishmaniasis (PKDL). The patient consented to having his picture published in the journal.

Citation: The American Society of Tropical Medicine and Hygiene 85, 2; 10.4269/ajtmh.2011.11-0128

Figure 2.
Figure 2.

Hypopigmented papules are seen on the patient's back. The lesions are roughly symmetrical, a common characteristic of post-kala-azar dermal leishmaniasis (PKDL), and are painless and non- pruritic.

Citation: The American Society of Tropical Medicine and Hygiene 85, 2; 10.4269/ajtmh.2011.11-0128

Figure 3.
Figure 3.

Hypopigmented papules on the abdomen.

Citation: The American Society of Tropical Medicine and Hygiene 85, 2; 10.4269/ajtmh.2011.11-0128

Figure 4.
Figure 4.

The patient has hypopigmented papules and plaques on both forearms. The absence of sensorineural changes helps to distinguish post-kala-azar dermal leishmaniasis (PKDL) from leprosy, which commonly presents with hypopigmented macules or patches associated with hypoesthesia or anesthesia, and neural thickening.

Citation: The American Society of Tropical Medicine and Hygiene 85, 2; 10.4269/ajtmh.2011.11-0128

Post-kala-azar dermal leishmaniasis (PKDL) is a chronic skin rash usually seen in apparently cured kala-azar patients in East Africa and South Asia. In the Indian subcontinent, the cumulative PKDL incidence after kala-azar is 5–10%.1 The PKDL usually presents with erythematous or hypopigmented papules or macules, sometimes progressing to plaques or nodules. Kala-azar patients treated with antimonial drugs may have poorer immune recovery and a higher risk of subsequent PKDL compared with those treated with amphotericin formulations.2 The only PKDL treatment regimens with proven efficacy in South Asia consist of 120 SSG injections over 6 months or miltefosine 2.5 mg/kg/day for 12 weeks. The PKDL patients are infectious to the sand fly vector and are thought to represent an important parasite reservoir in the anthroponotic transmission cycle of visceral leishmaniasis in South Asia.1

  • 1.

    Rahman KM, Islam S, Rahman MW, Kenah E, Chowdhury MG, Zahid MM, Maguire J, Rahman M, Haque R, Luby SP, Bern C, 2010. Rising incidence of post kala-azar dermal leishmaniasis in a population-based study in Bangladesh. Clin Infect Dis 50: 7376.

    • Search Google Scholar
    • Export Citation
  • 2.

    Saha S, Mondal S, Ravindran R, Bhowmick S, Modak D, Mallick S, Rahman M, Kar S, Goswami R, Gaha SK, Pramanik N, Saha B, Ali N, 2007. IL-10- and TGF-beta-mediated susceptibility in kala-azar and post-kala-azar dermal leishmaniasis: the significance of amphotericin B in the control of Leishmania donovani infection in India. J Immunol 179: 55925603.

    • Search Google Scholar
    • Export Citation

Author Notes

*Address correspondence to Caryn Bern, Division of Parasitic Diseases and Malaria, Center for Global Health, Centers for Disease Control and Prevention, MS F-22, 4770 Buford Highway NE, Atlanta, GA 30341. E-mail: cxb9@cdc.gov

Authors' addresses: Shamim Islam, Children's Hospital and Research Center Oakland, Oakland, CA, E-mail: sizuba@yahoo.com. M. Ashraful Alam Bhuiyan, ICDDR,B, Dhaka, Bangladesh, E-mail: aabhuiyan@icddrb.org. Caryn Bern, Division of Parasitic Diseases and Malaria, Center for Global Health, Centers for Disease Control and Prevention, Atlanta, GA, E-mail: cxb9@cdc.gov.

Save