The authors thank Kevin Haynes of the Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine for his assistance with database management. PLO initiated this research. FC, MAL, KR, CHC, DLC, SR, and SS contributed original data. MOH and MV compiled the database and conducted the analyses. All authors were involved in the conception, design, and interpretation of this analysis. MOH, PLO, and MB wrote the manuscript, and all authors participated in multiple rounds of edits and revisions. All authors have seen and approved the final draft submitted for review.
van Griensven J, Balasegaram M, Meheus F, Alvar J, Lynen L, Boelaert M, 2010. Combination therapy for visceral leishmaniasis. Lancet Infect Dis 10: 184–194.
Mubayi A, Castillo-Chavez C, Chowell G, Kribs-Zaleta C, Ali Siddiqui N, Kumar N, Das P, 2009. Transmission dynamics and underreporting of Kala-azar in the Indian state of Bihar. J Theor Biol 262: 177–185.
Adhikari SR, Maskay NM, 2003. The economic burden of Kala-azar in households of the Danusha and Mahottari districts of Nepal. Acta Trop 88: 1–2.
Adhikari SR, Maskay NM, Sharma BP, 2009. Paying for hospital-based care of Kala-azar in Nepal: assessing catastrophic, impoverishment and economic consequences. Health Policy Plan 24: 129–139.
Anoopa Sharma D, Bern C, Varghese B, Chowdhury R, Haque R, Ali M, Amann J, Ahluwalia IB, Wagatsuma Y, Breiman RF, Maguire JH, McFarland DA, 2006. The economic impact of visceral leishmaniasis on households in Bangladesh. Trop Med Int Health 11: 757–764.
Boelaert M, Meheus F, Sanchez A, Singh SP, Vanlerberghe V, Picado A, Meessen B, Sundar S, 2009. The poorest of the poor: a poverty appraisal of households affected by visceral leishmaniasis in Bihar, India. Trop Med Int Health 14: 639–644.
Meheus F, Boelaert M, Baltussen R, Sundar S, 2006. Costs of patient management of visceral leishmaniasis in Muzaffarpur, Bihar, India. Trop Med Int Health 11: 1715–1724.
Rijal S, Koirala S, Van der Stuyft P, Boelaert M, 2006. The economic burden of visceral leishmaniasis for households in Nepal. Trans R Soc Trop Med Hyg 100: 838–841.
Anstead GM, Chandrasekar B, Zhao W, Yang J, Perez LE, Melby PC, 2001. Malnutrition alters the innate immune response and increases early visceralization following Leishmania donovani infection. Infect Immun 69: 4709–4718.
Cerf BJ, Jones TC, Badaro R, Sampaio D, Teixeira R, Johnson WD Jr, 1987. Malnutrition as a risk factor for severe visceral leishmaniasis. J Infect Dis 156: 1030–1033.
Dye C, Williams BG, 1993. Malnutrition, age and the risk of parasitic disease: visceral leishmaniasis revisited. Proc Biol Sci 254: 33–39.
Harrison LH, Naidu TG, Drew JS, de Alencar JE, Pearson RD, 1986. Reciprocal relationships between undernutrition and the parasitic disease visceral leishmaniasis. Rev Infect Dis 8: 447–453.
Khalil EA, Zijlstra EE, Kager PA, El Hassan AM, 2002. Epidemiology and clinical manifestations of Leishmania donovani infection in two villages in an endemic area in eastern Sudan. Trop Med Int Health 7: 35–44.
Mueller Y, Mbulamberi DB, Odermatt P, Hoffmann A, Loutan L, Chappuis F, 2009. Risk factors for in-hospital mortality of visceral leishmaniasis patients in eastern Uganda. Trop Med Int Health 14: 910–917.
Kolaczinski JH, Reithinger R, Worku DT, Ocheng A, Kasimiro J, Kabatereine N, Brooker S, 2008. Risk factors of visceral leishmaniasis in East Africa: a case-control study in Pokot territory of Kenya and Uganda. Int J Epidemiol 37: 344–352.
Alvar J, Bashaye S, Argaw D, Cruz I, Aparicio P, Kassa A, Orfanos G, Parreno F, Babaniyi O, Gudeta N, Canavate C, Bern C, 2007. Kala-azar outbreak in Libo Kemkem, Ethiopia: epidemiologic and parasitologic assessment. Am J Trop Med Hyg 77: 275–282.
Herrero M, Orfanos G, Argaw D, Mulugeta A, Aparicio P, Parreno F, Bernal O, Rubens D, Pedraza J, Lima MA, Flevaud L, Palma PP, Bashaye S, Alvar J, Bern C, 2009. Natural history of a visceral leishmaniasis outbreak in highland Ethiopia. Am J Trop Med Hyg 81: 373–377.
Raguenaud ME, Jansson A, Vanlerberghe V, Van der Auwera G, Deborggraeve S, Dujardin JC, Orfanos G, Reid T, Boelaert M, 2007. Epidemiology and clinical features of patients with visceral leishmaniasis treated by an MSF clinic in Bakool Region, Somalia, 2004–2006. PLoS Negl Trop Dis 1: e85.
Rukunuzzaman M, Rahman M, 2008. Epidemiological study of risk factors related to childhood visceral leishmaniasis. Mymensingh Med J 17: 46–50.
World Health Organization, 2009. World Health Organization, United Nations Children's Fund. Child Growth Standards and the Identification of Severe Acute Malnutrition in Infants and Children. A Joint Statement by the World Health Organization and the United Nations Children's Fund. Available at: http://www.who.int/nutrition/publications/severemalnutrition/9789241598163/en/index.html. Accessed October 9, 2009.
World Health Organization, 2009. WHO Multicentre Growth Reference Study Group. WHO Child Growth Standards: Growth Velocity Based on Weight, Length and Head Circumference. Methods and Development. Geneva, Switzerland: World Health Organization.
de Onis M, Onyango AW, Borghi E, Siyam A, Nishida C, Siekmann J, 2007. Development of a WHO growth reference for school-aged children and adolescents. Bull World Health Organ 85: 660–667.
World Health Organization, 2009. BMI Classification. Global Database on Body Mass Index. Available at: http://apps.who.int/bmi/index.jsp?introPage=intro_3.html. Accessed October 9, 2009.
World Health Organization, 2009. WHO Anthro Software and Macros. Available at: http://www.who.int/entity/childgrowth/software/en. Accessed October 9, 2009.
World Health Organization, 2009. WHO Anthro Software and Macros (5–19 Years). Available at: http://www.who.int/growthref/tools/en/. Accessed October 9, 2009.
Taylor WR, Terlouw DJ, Olliaro PL, White NJ, Brasseur P, ter Kuile FO, 2006. Use of weight-for-age-data to optimize tablet strength and dosing regimens for a new fixed-dose artesunate-amodiaquine combination for treating falciparum malaria. Bull World Health Organ 84: 956–964.
World Health Organization Expert Consultation, 2004. Appropriate body-mass index for Asian populations and its implications for policy and intervention strategies. Lancet 363: 157–163.
van Buuren S, Hayes DJ, Stasinopoulos DM, Rigby RA, ter Kuile FO, Terlouw DJ, 2009. Estimating regional centile curves from mixed data sources and countries. Stat Med 28: 2891–2911.
Ritmeijer K, Davies C, van Zorge R, Wang SJ, Schorscher J, Dongu'du SI, Davidson RN, 2007. Evaluation of a mass distribution programme for fine-mesh impregnated bednets against visceral leishmaniasis in eastern Sudan. Trop Med Int Health 12: 404–414.
Olliaro P, Darley S, Laxminarayan R, Sundar S, 2009. Cost-effectiveness projections of single and combination therapies for visceral leishmaniasis in Bihar, India. Trop Med Int Health 14: 918–925.
Olliaro P, Sundar S, 2009. Anthropometrically derived dosing and drug costing calculations for treating visceral leishmaniasis in Bihar, India. Trop Med Int Health 14: 88–92.
den Boer ML, Alvar J, Davidson RN, Ritmeijer K, Balasegaram M, 2009. Developments in the treatment of visceral leishmaniasis. Expert Opin Emerg Drugs 14: 395–410.