Seoul virus, first identified in Korea in 1982,1 is one of multiple hantaviruses (family Bunyaviridae, genus Hantavirus) that cause hemorrhagic fever with renal syndrome (HFRS), mainly in Europe and Asia. Common clinical features include fever, myalgias, thrombocytopenia, leukocytosis, renal failure, and shock in the most severe cases.2 Elevation of liver enzymes is characteristic of HFRS caused by Seoul virus infection.3 Seoul virus is found worldwide and is transmitted by the brown Norway rat (Rattus norvegicus)1; humans can become infected and experience HFRS after exposure to aerosolized urine, droppings, or saliva from infected rodents. Only one confirmed case has been reported in the United States.4,5
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