A 34-year-old Peruvian female, 34 weeks pregnant, had burning pain and edema in the right thigh. A 1-cm asymptomatic nodular lesion preceded this complaint by 1 year. Treatment with dicloxacillin was followed by the lesion becoming red, swollen, and hot, accompanied by oozing. Despite additional dicloxacillin and clindamycin treatment, the lesion progressed, with the development of necrotic borders and, 2 months later, the appearance of four additional nodules on the same leg. Microscopic analysis of a skin biopsy showed acid-fast organisms; culture on Lowenstein Jensen medium initially grew colonies suggestive of Mycobacterium ulcerans but was finally reported as negative. Tissue polymerase chain reaction confirmed the identification of the organism.1 After delivery of a healthy baby, the patient was treated with streptomycin and rifampin for 8 weeks, and the open wound was treated with local surgery, resulting in complete cure (Figure 1).
Buruli ulcer is the third most common mycobacterial disease,2 usually acquired in tropical and subtropical regions of the Americas, Asia, Africa, and Australia. Typical manifestations are lower limb lesions, which may or may not ulcerate. These lesions are minimally painful but progress and lead to functional deficits and stigmatization.1–3 Treatment with rifampin and an aminoglycoside is usually curative.3 Treatment is often delayed because of lack of diagnostic suspicion or cost.
Authors’ addresses: Luz M. Moyano, Juan C. Chero, and Guillermo E. Gonzalvez, Cysticercosis Elimination Project, Av. Panamericana Norte s/n, Tumbes, Peru, Tel: +511 3287360, Fax: +511 3284038, E-mail:
Address correspondence to Guillermo E. Gonzalvez, Cysticercosis Elimination Project, Av. Panamericana Norte s/n, Tumbes, Peru. E-mail:
Acknowledgments: We thank M. Aznaran, I. Martinez, and M. Arredondo, from the regional office of the Peruvian Ministry of Health, for treatment and care of the patient, and Dr. H. Guerra, F. Portaels, and collaborators at the Tropical Medicine Institutes in Lima and Antwerp for facilities for culture and polymerase chain reaction.
World Health Organization, 2004. Provisional Guidance on the Role of Specific Antibiotics in the Management of Mycobacterium ulcerans Disease (Buruli Ulcer). Geneva: World Health Organization.