Experimental Infection of New World Monkeys with Dengue and Yellow Fever Viruses

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  • Laboratory of Tropical Diseases and Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, Bethesda 14, Md.


Thirty monkeys of six genera which occur in the New World were inoculated with strains of type 1 and type 2 dengue virus which had never been passaged in laboratory animals. Although none of the monkeys showed overt signs of illness, almost all developed hemagglutination-inhibition (HI) or neutralizing antibodies. Viremia was demonstrated in four species of monkeys of three different genera 4 to 6 days after inoculation.

The dengue and yellow fever HI antibody responses of these monkeys and others inoculated with yellow fever virus were similar to those which have been observed in persons naturally infected with these viruses.