Forty-two cases of cholera were examined for prothrombin time before administration of transfusion as well as after treatment. A definite decrease in prothrombin time was observed, which tended to become normal during convalescence. In some clinically severe cases, even after restoration of the blood to normal specific gravity, the prothrombin time remained low. The importance of the study of prothrombin and its relation to the various thrombotic phenomena that occur in cholera is evident.
In all cases of cholera superimposed on pregnancy, as in some cases of normal pregnancy, the prothrombin time was found to be reduced. In cholera cases this seems to be not an unmixed evil as there is a greatly reduced post partum hemorrhage which seldom extends beyond the first day.