Additive host genetic factors influence fecal egg excretion rates during Schistosoma mansoni infection in a rural area in Brazil.

J BethonyDepartment of Microbiology and Tropical Medicine, The George Washington University Medical Center, Washington, DC, USA.

Search for other papers by J Bethony in
Current site
Google Scholar
PubMed
Close
,
J T WilliamsDepartment of Microbiology and Tropical Medicine, The George Washington University Medical Center, Washington, DC, USA.

Search for other papers by J T Williams in
Current site
Google Scholar
PubMed
Close
,
J BlangeroDepartment of Microbiology and Tropical Medicine, The George Washington University Medical Center, Washington, DC, USA.

Search for other papers by J Blangero in
Current site
Google Scholar
PubMed
Close
,
H KloosDepartment of Microbiology and Tropical Medicine, The George Washington University Medical Center, Washington, DC, USA.

Search for other papers by H Kloos in
Current site
Google Scholar
PubMed
Close
,
A GazzinelliDepartment of Microbiology and Tropical Medicine, The George Washington University Medical Center, Washington, DC, USA.

Search for other papers by A Gazzinelli in
Current site
Google Scholar
PubMed
Close
,
B Soares-FilhoDepartment of Microbiology and Tropical Medicine, The George Washington University Medical Center, Washington, DC, USA.

Search for other papers by B Soares-Filho in
Current site
Google Scholar
PubMed
Close
,
L CoelhoDepartment of Microbiology and Tropical Medicine, The George Washington University Medical Center, Washington, DC, USA.

Search for other papers by L Coelho in
Current site
Google Scholar
PubMed
Close
,
L Alves-FragaDepartment of Microbiology and Tropical Medicine, The George Washington University Medical Center, Washington, DC, USA.

Search for other papers by L Alves-Fraga in
Current site
Google Scholar
PubMed
Close
,
S Williams-BlangeroDepartment of Microbiology and Tropical Medicine, The George Washington University Medical Center, Washington, DC, USA.

Search for other papers by S Williams-Blangero in
Current site
Google Scholar
PubMed
Close
,
P T LoverdeDepartment of Microbiology and Tropical Medicine, The George Washington University Medical Center, Washington, DC, USA.

Search for other papers by P T Loverde in
Current site
Google Scholar
PubMed
Close
, and
R Correa-OliveiraDepartment of Microbiology and Tropical Medicine, The George Washington University Medical Center, Washington, DC, USA.

Search for other papers by R Correa-Oliveira in
Current site
Google Scholar
PubMed
Close

This study quantifies the influence of shared household and kinship on egg counts during Schistosoma mansoni infection in a sample from rural Brazil. Detailed genealogic information allowed assignment of 597 individuals to 6 multihousehold pedigrees residing in 145 households. A variance component method was used to partition egg counts into shared household, additive genetic, and individual-specific environmental effects. Host additive genetic effects consistently accounted for a large proportion of the variation in egg counts: 43% in an unadjusted model and 40% in model adjusted for covariates. In a model that examined the confounding of shared household with kinship, additive genetic effects still accounted for 27% of the variation in egg counts and shared household only 12%. The consistently important role for host additive genetic factors on the variation in egg counts points to new ways of modeling and understanding the mechanisms that contribute to trait variation during infection with S. mansoni.

Save