Progressive Chagas' cardiomyopathy is associated with low selenium levels.

Maria Teresa RiveraDepartamento de Ultra-estrutura e Biologia Celular, Instituto Oswaldo Cruz, Fiocruz, Rio de Janeiro, RJ, Brazil.

Search for other papers by Maria Teresa Rivera in
Current site
Google Scholar
PubMed
Close
,
Andréa P de SouzaDepartamento de Ultra-estrutura e Biologia Celular, Instituto Oswaldo Cruz, Fiocruz, Rio de Janeiro, RJ, Brazil.

Search for other papers by Andréa P de Souza in
Current site
Google Scholar
PubMed
Close
,
Alejandro M Hasslocher MorenoDepartamento de Ultra-estrutura e Biologia Celular, Instituto Oswaldo Cruz, Fiocruz, Rio de Janeiro, RJ, Brazil.

Search for other papers by Alejandro M Hasslocher Moreno in
Current site
Google Scholar
PubMed
Close
,
Sergio S XavierDepartamento de Ultra-estrutura e Biologia Celular, Instituto Oswaldo Cruz, Fiocruz, Rio de Janeiro, RJ, Brazil.

Search for other papers by Sergio S Xavier in
Current site
Google Scholar
PubMed
Close
,
Juliana A S GomesDepartamento de Ultra-estrutura e Biologia Celular, Instituto Oswaldo Cruz, Fiocruz, Rio de Janeiro, RJ, Brazil.

Search for other papers by Juliana A S Gomes in
Current site
Google Scholar
PubMed
Close
,
Manoel Otávio C RochaDepartamento de Ultra-estrutura e Biologia Celular, Instituto Oswaldo Cruz, Fiocruz, Rio de Janeiro, RJ, Brazil.

Search for other papers by Manoel Otávio C Rocha in
Current site
Google Scholar
PubMed
Close
,
Rodrigo Correa-OliveiraDepartamento de Ultra-estrutura e Biologia Celular, Instituto Oswaldo Cruz, Fiocruz, Rio de Janeiro, RJ, Brazil.

Search for other papers by Rodrigo Correa-Oliveira in
Current site
Google Scholar
PubMed
Close
,
Jean NèveDepartamento de Ultra-estrutura e Biologia Celular, Instituto Oswaldo Cruz, Fiocruz, Rio de Janeiro, RJ, Brazil.

Search for other papers by Jean Nève in
Current site
Google Scholar
PubMed
Close
,
Jean VanderpasDepartamento de Ultra-estrutura e Biologia Celular, Instituto Oswaldo Cruz, Fiocruz, Rio de Janeiro, RJ, Brazil.

Search for other papers by Jean Vanderpas in
Current site
Google Scholar
PubMed
Close
, and
Tania C Araújo-JorgeDepartamento de Ultra-estrutura e Biologia Celular, Instituto Oswaldo Cruz, Fiocruz, Rio de Janeiro, RJ, Brazil.

Search for other papers by Tania C Araújo-Jorge in
Current site
Google Scholar
PubMed
Close

Selenium (Se) deficiency is linked with some cardiomyopathies. Its status was determined in 170 patients with chronic Chagas' disease from 2 Brazilian regions (Rio de Janeiro and Belo Horizonte), clinically stratified into groups as follows: indeterminate or asymptomatic (IND); cardiac asymptomatic (CARDa); cardiac symptomatic with moderate to severe heart dysfunction (CARDb); and healthy adults (HA), used for comparison. In most HA, Se levels were normal, excluding an overall Se deficiency. Se was significantly lower in CARDb than in HA, IND, or CARDa patients. This was not associated with a concomitant decrease in activity of glutathione peroxidase. Thyrotropin was normal, excluding iodine deficiency. Se correlated positive and significantly with ventricular ejection fraction (assessed via echocardiography). Asymptomatic children with acute Chagas' disease had normal Se as well as 5 noninfectious cases of cardiomyopathy. Low Se was found in 6 of 10 chagasic patients with digestive megasyndromes. Thus, the decrease in Se in chagasic patients seems to be a biological marker for Trypanosoma cruzi infection and related to the progression of pathology.

Save