Influence of human T-cell lymphocytotropic virus type 1 infection on serologic and skin tests for strongyloidiasis.

A F PortoServiço de Imunologia do Hospital Universitário Prof Edgard Santos, Universidade Federal da Bahia, Brazil.

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J Oliveira FilhoServiço de Imunologia do Hospital Universitário Prof Edgard Santos, Universidade Federal da Bahia, Brazil.

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F A NevaServiço de Imunologia do Hospital Universitário Prof Edgard Santos, Universidade Federal da Bahia, Brazil.

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G OrgeServiço de Imunologia do Hospital Universitário Prof Edgard Santos, Universidade Federal da Bahia, Brazil.

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L AlcântaraServiço de Imunologia do Hospital Universitário Prof Edgard Santos, Universidade Federal da Bahia, Brazil.

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A GamServiço de Imunologia do Hospital Universitário Prof Edgard Santos, Universidade Federal da Bahia, Brazil.

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E M CarvalhoServiço de Imunologia do Hospital Universitário Prof Edgard Santos, Universidade Federal da Bahia, Brazil.

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The aim of this study was to determine whether human T-cell lymphocytotropic virus type 1 (HTLV-1) infection may affect the levels of parasite-specific immunoglobulin (Ig) G and IgE and the positivity of the skin test for strongyloidiasis. Participants included 67 patients with strongyloidiasis (40 without HTLV-1 infection and 27 coinfected with HTLV-1). We determined IgG and IgE levels by enzyme-linked immunosorbent assay, and the immediate hypersensitivity skin test was performed with the metabolic Strongyloides stercoralis antigen. Specific IgE levels and the size of skin reactions in patients without HTLV-1 were higher (P < 0.01) than those observed in patients coinfected with HTLV-1. Additionally, 89% of patients without HTLV-1 had specific IgE and 92.5% had positive skin tests; however, these values were significantly reduced (P < 0.01) in patients coinfected with HTLV-1 (44% and 59%, respectively). These data show that HTLV-1 infection decreases the sensitivity of detection of S. stercoralis-specific IgE, the size of the immediate hypersensitivity reaction, and the sensitivity of these tests in the diagnosis of strongyloidiasis.

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