Previously,1 we reported on a retrospective study of the clinical records of 318 neurosyphilitic patients who were treated by infection with the El Limon, Santee Cooper, and McLendon strains of Plasmodium falciparum either via sporozoite or trophozoite inoculation. No records indicated that these patients had been infected previously with Plasmodium. Here, we report a similar examination of the clinical records of patients reinfected with homologous and heterologous strains of P. falciparum.
These studies were conducted at the National Institutes of Health laboratories in Columbia, South Carolina and Milledgeville, Georgia during the period 1940 to 1963.
Collins WE, Jeffery GM, 1999. A retrospective examination of sporozoite- and trophozoite-induced infections with Plasmodium falciparum: development of parasitologic and clinical immunity during primary infection. Am J Trop Med Hyg 61: (suppl):4–19.
Young MD, Hardman NF, Burgess RW, Frohne WC, Sabrosky CW, 1948. The infectivity of native malarias in South Carolina to Anopheles quadrimaculatus. Am J Trop Med 28: 303–311.
Jeffery GM, Eyles DE, Young MD, 1950. The comparative susceptibility of Anopheles quadrimaculatus and two strains of Anopheles albimanus to a Panama strain of Plasmodium falciparum. J Natl Malaria Soc 9: 349–355.
Eyles DE, Young MD, 1950. The comparative susceptibility of Anopheles albimanus and Anopheles quadrimaculatus to a South Carolina strain of Plasmodium falciparum. J Infect Dis 87: 189–193.
Young MD, Contacis PG, Stitcher JE, Millar JW, 1963. Drug resistance in Plasmodium falciparum from Thailand. Am J Trop Med Hyg 12: 305–314.
Mayne B, Young MD, 1941. The technique of induced malaria as used in the South Carolina State Hospital. Venereal Dis Information 22: 271–276.
Collins WE, Collins GM, 1962. Methods and techniques for the handling of mosquitoes in human and animal malaria studies. Proceedings of the 49th Annual Meeting of the New Jersey Mosquito Extermination Association, 188–195.