This paper describes rare and previously unreported histopathologic conditions found at autopsy in cases of Manson's schistosomiasis. Schistosome eggs were seen in the thyroid gland, spleen, lungs, pancreas, stomach, duodenum, prostate gland and adrenals. Of particular interest were an egg found in a Malpighian corpuscle in the spleen, and an egg with ruptured shell and liberated miracidium found in a pulmonary granuloma. An egg found in the lumen of a large bronchus appeared to be the pathological counterpart of schistosome eggs in the sputum. The finding of worms in the varicose veins of the esophagus and in veins within the spleen and pancreas was a particularly rare occurrence. Theories to explain the findings of schistosome eggs and worms in the various rare locations are presented in the body of the paper.