Increases in the Effects of Albendazole on Echinococcus multilocularis Metacestodes by the Dipeptide Methyl Ester (Phe-Phe-OMe)

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  • Department of Parasitology and Medical Mycology, Medicinal Chemistry, and Laboratory of Pharmacology and Medical Toxicology, Institut National de la Sante et de la Recherche Medicale Unite 80, Claude Bernard University, Lyon, France

Three months after infection with Echinococcus multilocularis, Mongolian gerbils were given either the dipeptide methyl ester (Phe-Phe-OMe) or a combination of Phe-Phe-OMe plus albendazole to treat alveolar echinococcosis. Each drug was given orally at the daily dose of 50 mg/kg of body weight following various administration regimens. Histologic and ultrastructural studies of parasites recovered from infected gerbil tissues showed that the dipeptide methyl ester increases the effect of albendazole.

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