Department of Pathology, Institute of Tropical Medicine, Nagasaki University, Histology Department, Rift Valley Provincial Hospital, Institute of Molecular Medicine and Technology, Huntington Memorial Hospital, Nagasaki, Japan
Recently, the unique nucleic acid closely related to the herpes-like sequences has been found in acquired immunodeficiency syndrome (AIDS)-associated Kaposi's sarcoma (KS). We have confirmed the presence of herpes-like DNA sequences in six cases of AIDS-associated KS and three of the nine cases of African-endemic KS in adults, but not in eight cases of KS in children from the same area. These sequences were seen in a histologically early stage of KS. Our results suggest that herpes-like DNA sequences may play an important role in the pathogenesis of AIDS-associated KS.