Antibody Response to Plasmodium vivax Antigens in Human Malaria

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  • Departamento de Inmunologia, Instituto de Investigaciones Biomedicas, and Instituto de Investigaciones en Matematicas Aplicadas y en Sistemas, Universidad Nacional Autonoma de Mexico, Centro de Investigacion de Paludismo, SSA Tapachula, Mexico, DF, Mexico

The present study investigated the serum antibody response to parasite antigens involved in human Plasmodium vivax malaria. Analysis was performed by protein immunoblotting of a pool of P. vivax preparations obtained from blood of patients from Tapachula, Chiapas (southeastern Mexico), and sera from local malarious patients. Patients sera recognized 19 P. vivax antigens with molecular sizes between 17 and 170 kD. The most frequently recognized antigens were proteins of 19, 31, 43, 72, 93, and 97 kD. These proteins could be useful in diagnostic methods and possibly relevant in vaccine design.