RO 2-1160, a New Drug for the Treatment of Amebiasis

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  • Department of Preventive Medicine, N. Y. U.—Bellevue Medical Center and the Tropical, Disease Diagnostic Clinic (Lower East Side Health Center), New York City Health Department, New York

Ro 2-1160, a new pentavalent aromatic stibonic acid (2-carboxymethyl-mercapto-benzine stibonic acid) has been found to be significantly active in curing experimentally induced E. histolytica infections in the rat, well tolerated by dogs, and relatively non-toxic in small animals (Schnitzer, 1954; Schnitzer et al., 1951). The present report deals with the results of trials with this agent in human colonic amebiasis.

Materials and Methods. The patients were treated and studied at the Tropical Disease Diagnostic Clinic (Lower East Side Health Center, New York City Health Department). The diagnosis of amebiasis was established by the demonstration of cysts and/or trophozoites of E. histolytica in casually passed or post-cathartic fecal specimens (direct smear and zinc sulphate centrifugal flotation). After therapy, stool specimens were usually examined at least at tri-weekly intervals. One or more post-cathartic specimens were examined in most cases, usually one month after therapy and subsequently at 1–3 month intervals up to 12 months, in so far as practical.