Erythromycin was found of value in the treatment of acute amebic dysentery. The drug was given to ten cases in a dose of 1.2 gm. daily for a period of 10 days and in a similar dose to another group for a period of 5 days. Marked improvement appeared in both groups, but two cases relapsed in the second group, while no relapses occurred in the first. The follow up is not complete however, as it was continued only for an average of 3 months. It is suggested that further trials be made, with a longer period of observation.