Program in Comparative Medicine and Department of Pathology, Division of Geographic Medicine, Department of Medicine, and Division of Infectious Diseases, University of Maryland School of Medicine, Department of Veterans Affairs Medical Center, Department of Bacterial Diseases, Walter Reed Army Institute of Research, Washington, District of Columbia, Instituto de Salud Publica, AVDA Marathon 100, Baltimore, Maryland, Chile
The serologic response to Helicobacter pylori was determined in 388 children and teenagers living in Iquique, Chile by using an IgG enzyme-linked immunosorbent assay. Serum antibody levels, as measured by optical density, correlated strongly with age. Increases in the mean antibody level were seen primarily after age five, with rates of seropositivity increasing to ≥ 70% among teenagers. The reasons for this age-related pattern of acquisition of infection remain to be determined.