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Acute Sporadic Hepatitis E in an Egyptian Pediatric Population
Dina Mohamed Tawfik El-Zimaity
Dina Mohamed Tawfik El-Zimaity
Microbiology Department, Benha University, Division of Epidemiology, Naval Medical Research Institute, U.S. Naval Medical Research Unit No. 3, Assuit University, Abbassia Fever Hospital, Hepatitis Branch, Centers for Disease Control, Benha, Egypt
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Kenneth C. Hyams
Kenneth C. Hyams
Microbiology Department, Benha University, Division of Epidemiology, Naval Medical Research Institute, U.S. Naval Medical Research Unit No. 3, Assuit University, Abbassia Fever Hospital, Hepatitis Branch, Centers for Disease Control, Benha, Egypt
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Imam Z. E. Imam
Imam Z. E. Imam
Microbiology Department, Benha University, Division of Epidemiology, Naval Medical Research Institute, U.S. Naval Medical Research Unit No. 3, Assuit University, Abbassia Fever Hospital, Hepatitis Branch, Centers for Disease Control, Benha, Egypt
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Douglas M. Watts
Douglas M. Watts
Microbiology Department, Benha University, Division of Epidemiology, Naval Medical Research Institute, U.S. Naval Medical Research Unit No. 3, Assuit University, Abbassia Fever Hospital, Hepatitis Branch, Centers for Disease Control, Benha, Egypt
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Samir Bassily
Samir Bassily
Microbiology Department, Benha University, Division of Epidemiology, Naval Medical Research Institute, U.S. Naval Medical Research Unit No. 3, Assuit University, Abbassia Fever Hospital, Hepatitis Branch, Centers for Disease Control, Benha, Egypt
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Emad Kamel Naffea
Emad Kamel Naffea
Microbiology Department, Benha University, Division of Epidemiology, Naval Medical Research Institute, U.S. Naval Medical Research Unit No. 3, Assuit University, Abbassia Fever Hospital, Hepatitis Branch, Centers for Disease Control, Benha, Egypt
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Yehia Sultan
Yehia Sultan
Microbiology Department, Benha University, Division of Epidemiology, Naval Medical Research Institute, U.S. Naval Medical Research Unit No. 3, Assuit University, Abbassia Fever Hospital, Hepatitis Branch, Centers for Disease Control, Benha, Egypt
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Kadry Emara
Kadry Emara
Microbiology Department, Benha University, Division of Epidemiology, Naval Medical Research Institute, U.S. Naval Medical Research Unit No. 3, Assuit University, Abbassia Fever Hospital, Hepatitis Branch, Centers for Disease Control, Benha, Egypt
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Jim Burans
Jim Burans
Microbiology Department, Benha University, Division of Epidemiology, Naval Medical Research Institute, U.S. Naval Medical Research Unit No. 3, Assuit University, Abbassia Fever Hospital, Hepatitis Branch, Centers for Disease Control, Benha, Egypt
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Michael A. Purdy
Michael A. Purdy
Microbiology Department, Benha University, Division of Epidemiology, Naval Medical Research Institute, U.S. Naval Medical Research Unit No. 3, Assuit University, Abbassia Fever Hospital, Hepatitis Branch, Centers for Disease Control, Benha, Egypt
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Daniel W. Bradley
Daniel W. Bradley
Microbiology Department, Benha University, Division of Epidemiology, Naval Medical Research Institute, U.S. Naval Medical Research Unit No. 3, Assuit University, Abbassia Fever Hospital, Hepatitis Branch, Centers for Disease Control, Benha, Egypt
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Mitchell Carl
Mitchell Carl
Microbiology Department, Benha University, Division of Epidemiology, Naval Medical Research Institute, U.S. Naval Medical Research Unit No. 3, Assuit University, Abbassia Fever Hospital, Hepatitis Branch, Centers for Disease Control, Benha, Egypt
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A study was conducted to determine the etiology of acute hepatitis among 261 children (age range 1–11 years) living in Cairo, Egypt. A blood sample was obtained from each subject when initially evaluated and a questionnaire was used to collect demographic and risk factor data. Sera were tested by enzyme immunoassay for acute hepatitis A (anti-hepatitis A virus IgM), hepatitis B (anti-hepatitis B core antigen IgM and hepatitis B surface antigen [HBsAg]), hepatitis C (total anti-HCV), delta hepatitis (total anti-delta), and cytomegalovirus infection (anti-CMV IgM). In addition, hepatitis E virus (HEV) infection was diagnosed using a new Western blot technique to test patients with non-A, non-B hepatitis for anti-HEV IgM. Among 261 children, acute hepatitis A was diagnosed in 85 (32.6%) patients, acute hepatitis B in 19 (7.3%), delta hepatitis in 3 (1.1%), mixed hepatitis A and B infection in 2 (0.8%), CMV infection in 1 (0.4%), hepatitis E in 58 (22.2%), and non-A, non-B hepatitis of unknown type in 51 (19.5%). Forty-two (16.1%) subjects had HBsAg without other markers of acute infection. Risk factor analysis indicated that patients living in homes not connected to a municipal source of water were at increased risk of hepatitis E infection. These data provide additional evidence that hepatitis E virus is a common cause of acute sporadic hepatitis in children living in Egypt.
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| Past two years | Past Year | Past 30 Days | |
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| PDF Downloads | 13 | 3 | 0 |