Reactions with Drug Therapy

by Harry L. Alexander, M.D., W.B. Emeritus Professor of Clinical Medicine, George Washington University Medical School; formerly Editor of the Journal of Allergy. Saunders Co., Philadelphia, 1955, 301 pages with index

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This monograph by a former editor of the Journal of Allergy is well timed and very properly oriented. No other concise source of such material, as covered in this book, is available. While there is extensive literature on qualitative untoward drug reactions, the common offenders, especially those causing dermatoses, are probably limited to not more than 1,000 agents. Despite the opinion that practically any drug is allergenic, a comparatively small number of common lesions account for most reactions.

Thus, after an appropriate introduction, the author has dealt with the subject in a simplified fashion and in a very direct manner. The second chapter is concerned with the mechanisms of “hypersensitivity,” in contrast to expected pharmacologic responses to drugs.

The third chapter deals with dermatologic manifestations, and falls into the classification usually preferred by dermatologists. Chapter IV deals with systemic patterns, including blood dyscrasias, serum sickness, hepatitis, and so on.

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