This talk will be a sketchy history of the mosquito-borne virus encephalitides in the United States. I have tried to select those efforts and findings which have strongly influenced the course of development in this field. You should not be at all surprised to find William C. Reeves inextricably involved throughout. After all, he has worked on the virus encephalitides essentially all of his adult life. As an eminent investigator, leader, and teacher, he has in great part set the pace and been responsible for our present high state of knowledge in this area.
The viruses to be considered are western equine encephalomyelitis (WEE), eastern equine encephalomyelitis (EEE), St. Louis encephalitis (SLE), and the California serogroup. I was tempted to include Venezuelan equine encephalitis (VEE) also, as it is a fascinating subject.