Adoptive Transfer of Vaccine-Induced Resistance to Leishmania Donovani

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  • Departments of Laboratory Medicine and Ophthalmology, Medical University of South Carolina, Charleston, South Carolina 29425

BALB/c mice were immunized with three subcutaneous injections combining killed parasites and glucan, or were untreated. Spleen cells were transferred to syngeneic recipients. Mice which received 5 × 108 spleen cells from vaccinated donors demonstrated significant protection against Leishmania donovani challenge as compared to untreated mice receiving immune sera, or mice which received untreated spleen cells.