A Role for 8-Aminoquinolines in Falciparum Malaria?

A Pan American Health Organization (PAHO) workshop, held in 1962 and just recently reported was concerned with malaria in the Americas. The principal reason for holding the workshop was the recognition of the failure of present programs to control the malarias in the Americas, particularly falciparum malaria. The prime causes claimed were insecticide failure and parasite drug resistance, a combination that the participants seem to infer led to a reorientation of antimalarial measures by the World Health Organization in 1969 and by PAHO in 1982.

There was considerable discussion of Plasmodium falciparum resistance to the 4-aminoquinolines and to mefloquine. The participants also took note of the increasing number of cases that were failing to respond to a sulfadoxine-pyrimethamine combination.

Much attention was paid to the apparent absence of 4-aminoquinoline resistance in much of Central America (less Panama) and in Hispaniola.

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