Developments in Biological Standardization, vol. 54. Viral Hepatitis: Standardization in Immunoprophylaxis of Infections by Hepatitis Viruses

edited by G. Papaevangelou and W. Hennessen. xviii + 590 pages. S. Karger AG, Basel, P.O. Box CH-4009, Basel, Switzerland, 1983. $81.00

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  • Division of Infectious Diseases, Department of Medicine, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27514

In November 1982, a symposium was held in Athens, Greece, under the auspices of the International Association of Biological Standardization and the World Health Organization. The focus of this symposium was on problems related to the development and production of vaccines and human immunoglobulin products for immunoprophylaxis against viral hepatitis. This volume represents the proceedings of this conference, and its 585 pages provide a nice summary of many of the advances which had taken place in this field during the 8 intervening years since the First IABS Symposium on Viral Hepatitis was held in Milan in 1974. To a great extent, it was the rapid development of plasma-derived vaccines for hepatitis B in several different countries that prompted the convening of the symposium. It is, therefore, no surprise that much of this book deals with active immunization against hepatitis B, with topics including standardization of hepatitis B vaccines and the immune response to them, future sources of antigen for vaccine production, efficacy trials of hepatitis B vaccines, and global strategies for active immunization.