Predisposition to Brugia Malayi Microfilaremia in Progeny of Infected Gerbils

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  • Department of Tropical Public Health, Harvard School of Public Health, 665 Huntington Avenue, Boston, Massachusetts 02115

Patency of Brugia malayi infection in gerbils born of infected parents was compared to that in gerbils from noninfected parents. Following infection with third stage larvae, female progeny of infected parents generally became microfilaremic whereas those of noninfected parents rarely did so. Male progeny developed microfilaremia regardless of parentage, although descendants of infected parents tended to have higher parasitemia. We conclude that B. malayi infection in the mother predisposes the offspring to patent infection subsequent to inoculation with infective larvae.

Author Notes

Present address: Department of Biological Sciences, Clark Science Center, Smith College, Northampton, Massachusetts 01063. Send reprint requests to this address.

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