In Vitro Study of Drug Sensitivity of Plasmodium Falciparum: Evaluation of a New Semi-Micro Test

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  • Laboratoire de Parasitologie and Institut de Médecine et d'Epidémiologie Tropicales, Hôpital Claude Bernard, 10 avenue de la Porte d'Aubervilliers, 75019 Paris, France

A modification of Rieckmann's microtechnique was used to determine the drug sensitivity of Plasmodium falciparum. The technique was found to be reliable and adequately sensitive with either blood from a malarial patient or strains of P. falciparum from in vitro continuous culture, with a success rate of 50%. Minor variations in the method had little influence on the results. Inhibition of maturation of parasites was compared with the inhibition of increase in parasitemia.