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Antitrypanosomal Activity of Sinefungin

Dipak K. Dube International Laboratory for Research on Animal Diseases (I.L.R.A.D.), P.O. Box 30709, Centre d'Immunologies Inserm-CNRS, Marseille Luminy, Case No. 906, 13283 Marseille Cedex 9, Laboratoire de Biochimie, C.N.R.S., 91190 Gif-sur-Yvette, Nairobi, Kenya

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George Mpimbaza International Laboratory for Research on Animal Diseases (I.L.R.A.D.), P.O. Box 30709, Centre d'Immunologies Inserm-CNRS, Marseille Luminy, Case No. 906, 13283 Marseille Cedex 9, Laboratoire de Biochimie, C.N.R.S., 91190 Gif-sur-Yvette, Nairobi, Kenya

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Anthony C. Allison International Laboratory for Research on Animal Diseases (I.L.R.A.D.), P.O. Box 30709, Centre d'Immunologies Inserm-CNRS, Marseille Luminy, Case No. 906, 13283 Marseille Cedex 9, Laboratoire de Biochimie, C.N.R.S., 91190 Gif-sur-Yvette, Nairobi, Kenya

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Edgar Lederer International Laboratory for Research on Animal Diseases (I.L.R.A.D.), P.O. Box 30709, Centre d'Immunologies Inserm-CNRS, Marseille Luminy, Case No. 906, 13283 Marseille Cedex 9, Laboratoire de Biochimie, C.N.R.S., 91190 Gif-sur-Yvette, Nairobi, Kenya

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Luciana Rovis International Laboratory for Research on Animal Diseases (I.L.R.A.D.), P.O. Box 30709, Centre d'Immunologies Inserm-CNRS, Marseille Luminy, Case No. 906, 13283 Marseille Cedex 9, Laboratoire de Biochimie, C.N.R.S., 91190 Gif-sur-Yvette, Nairobi, Kenya

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DOI:
https://doi.org/10.4269/ajtmh.1983.32.31
Volume/Issue:
Volume 32: Issue 1
Page(s):
31–33
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Sinefungin, a naturally occurring antifungal antibiotic nucleoside containing an ornithine residue, linked by a C-C bond to C-5′ of adenosine, cures mice infected with Trypanosoma brucei brucei, T. congolense, or T. vivax; the effect of the drug is more pronounced towards T. congolense. Anti-trypanosomal activity of sinefungin could be the result of the inhibition of transmethylation reactions or of polyamine biosynthesis—or both—in parasites.

Author Notes

Present address: Department of Pathology, SN-30, University of Washington, Seattle, Washington 98195.

Copyright:
Copyright © 1983 The American Society of Tropical Medicine and Hygiene 1983
Accepted:
05 May 1982
|
Published Online:
Jan 1983
Cover The American Journal of Tropical Medicine and Hygiene
The American Journal of Tropical Medicine and Hygiene
Print ISSN:
0002-9637
Volume 32: Issue 1
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