Antitrypanosomal Activity of Sinefungin

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  • International Laboratory for Research on Animal Diseases (I.L.R.A.D.), P.O. Box 30709, Centre d'Immunologies Inserm-CNRS, Marseille Luminy, Case No. 906, 13283 Marseille Cedex 9, Laboratoire de Biochimie, C.N.R.S., 91190 Gif-sur-Yvette, Nairobi, Kenya

Sinefungin, a naturally occurring antifungal antibiotic nucleoside containing an ornithine residue, linked by a C-C bond to C-5′ of adenosine, cures mice infected with Trypanosoma brucei brucei, T. congolense, or T. vivax; the effect of the drug is more pronounced towards T. congolense. Anti-trypanosomal activity of sinefungin could be the result of the inhibition of transmethylation reactions or of polyamine biosynthesis—or both—in parasites.

Author Notes

Present address: Department of Pathology, SN-30, University of Washington, Seattle, Washington 98195.