This site uses cookies, tags, and tracking settings to store information that help give you the very best browsing experience. Dismiss this warning

Original Antigenic Sin in Dengue

Scott B. Halstead Department of Tropical Medicine and Medical Microbiology, University of Hawaii School of Medicine, 3675 Kilauea Avenue, Virus Research Institute, Department of Medical Sciences, Ministry of Public Health, Honolulu, Hawaii 96816, Thailand

Search for other papers by Scott B. Halstead in
Current site
Google Scholar
PubMed Close
,
Suntharee Rojanasuphot Department of Tropical Medicine and Medical Microbiology, University of Hawaii School of Medicine, 3675 Kilauea Avenue, Virus Research Institute, Department of Medical Sciences, Ministry of Public Health, Honolulu, Hawaii 96816, Thailand

Search for other papers by Suntharee Rojanasuphot in
Current site
Google Scholar
PubMed Close
, and
Nadhirat Sangkawibha Department of Tropical Medicine and Medical Microbiology, University of Hawaii School of Medicine, 3675 Kilauea Avenue, Virus Research Institute, Department of Medical Sciences, Ministry of Public Health, Honolulu, Hawaii 96816, Thailand

Search for other papers by Nadhirat Sangkawibha in
Current site
Google Scholar
PubMed Close
DOI:
https://doi.org/10.4269/ajtmh.1983.32.154
Volume/Issue:
Volume 32: Issue 1
Page(s):
154–156
Restricted access
Get Permissions

Sequential blood samples were obtained from eight Thai children before, during and 3–5 months after hospitalization for dengue shock syndrome. All patients experienced a secondary-type antibody response as evidenced by hemagglutination-inhibition antibody responses in acute and convalescent sera. Dengue 2 viruses were recovered from two patients. In their pre-illness blood sample, all children had monotypic neutralizing antibodies; five to dengue 1, two to dengue 3 and one to dengue 4. The highest neutralizing antibody titers in acute phase and late convalescent sera were to the initial infecting virus type. This report documents for sequential dengue infections the existence of an original antigenic sin antibody response. It may be possible to apply this phenomenon to identify initial dengue serotype infection in individuals experiencing secondary dengue infections, thus helping to clarify the antecedents to dengue shock syndrome.

Author Notes

Copyright:
Copyright © 1983 The American Society of Tropical Medicine and Hygiene 1983
Accepted:
10 Jun 1982
|
Published Online:
Jan 1983
Cover The American Journal of Tropical Medicine and Hygiene
The American Journal of Tropical Medicine and Hygiene
Print ISSN:
0002-9637
Volume 32: Issue 1
Ahead of Print
Volume: 111 (2024)
Show Items
Volume: 110 (2024)
Show Items
Volume: 109 (2023)
Show Items
Volume: 108 (2023)
Show Items
Volume: 107 (2022)
Show Items
Volume: 106 (2022)
Show Items
Volume: 105 (2021)
Show Items
Volume: 104 (2021)
Show Items
Volume: 103 (2020)
Show Items
Volume: 102 (2020)
Show Items
Volume: 101 (2019)
Show Items
Volume: 100 (2019)
Show Items
Volume: 99 (2018)
Show Items
Volume: 98 (2018)
Show Items
Volume: 97 (2017)
Show Items
Volume: 96 (2017)
Show Items
Volume: 95 (2016)
Show Items
Volume: 94 (2016)
Show Items
Volume: 93 (2015)
Show Items
Volume: 92 (2015)
Show Items
Volume: 91 (2014)
Show Items
Volume: 90 (2014)
Show Items
Volume: 89 (2013)
Show Items
Volume: 88 (2013)
Show Items
Volume: 87 (2012)
Show Items
Volume: 86 (2012)
Show Items
Volume: 85 (2011)
Show Items
Volume: 84 (2011)
Show Items
Volume: 83 (2010)
Show Items
Volume: 82 (2010)
Show Items
Volume: 81 (2009)
Show Items
Volume: 80 (2009)
Show Items
Volume: 79 (2008)
Show Items
Volume: 78 (2008)
Show Items
Volume: 77 (2007)
Show Items
Volume: 76 (2007)
Show Items
Volume: 75 (2006)
Show Items
Volume: 74 (2006)
Show Items
Volume: 73 (2005)
Show Items
Volume: 72 (2005)
Show Items
Volume: 71 (2004)
Show Items
Volume: 70 (2004)
Show Items
Volume: 69 (2003)
Show Items
Volume: 68 (2003)
Show Items
Volume: 67 (2002)
Show Items
Volume: 66 (2002)
Show Items
Volume: 65 (2001)
Show Items
Volume: 64 (2001)
Show Items
Volume: 63 (2000)
Show Items
Volume: 62 (2000)
Show Items
Volume: 61 (1999)
Show Items
Volume: 60 (1999)
Show Items
Volume: 59 (1998)
Show Items
Volume: 58 (1998)
Show Items
Volume: 57 (1997)
Show Items
Volume: 56 (1997)
Show Items
Volume: 55 (1996)
Show Items
Volume: 54 (1996)
Show Items
Volume: 53 (1995)
Show Items
Volume: 52 (1995)
Show Items
Volume: 51 (1994)
Show Items
Volume: 50 (1994)
Show Items
Volume: 49 (1993)
Show Items
Volume: 48 (1993)
Show Items
Volume: 47 (1992)
Show Items
Volume: 46 (1992)
Show Items
Volume: 45 (1991)
Show Items
Volume: 44 (1991)
Show Items
Volume: 43 (1990)
Show Items
Volume: 42 (1990)
Show Items
Volume: 41 (1989)
Show Items
Volume: 40 (1989)
Show Items
Volume: 39 (1988)
Show Items
Volume: 38 (1988)
Show Items
Volume: 37 (1987)
Show Items
Volume: 36 (1987)
Show Items
Volume: 35 (1986)
Show Items
Volume: 34 (1985)
Show Items
Volume: 33 (1984)
Show Items
Volume: 32 (1983)
Show Items
Volume: 31 (1982)
Show Items
Volume: 30 (1981)
Show Items
Volume: 29 (1980)
Show Items
Volume: 28 (1979)
Show Items
Volume: 27 (1978)
Show Items
Volume: 26 (1977)
Show Items
Volume: 25 (1976)
Show Items
Volume: 24 (1975)
Show Items
Volume: 23 (1974)
Show Items
Volume: 22 (1973)
Show Items
Volume: 21 (1972)
Show Items
Volume: 20 (1971)
Show Items
Volume: 19 (1970)
Show Items
Volume: 18 (1969)
Show Items
Volume: 17 (1968)
Show Items
Volume: 16 (1967)
Show Items
Volume: 15 (1966)
Show Items
Volume: 14 (1965)
Show Items
Volume: 13 (1964)
Show Items
Volume: 12 (1963)
Show Items
Volume: 11 (1962)
Show Items
Volume: 10 (1961)
Show Items
Volume: 9 (1960)
Show Items
Volume: 8 (1959)
Show Items
Volume: 7 (1958)
Show Items
Volume: 6 (1957)
Show Items
Volume: 5 (1956)
Show Items
Volume: 4 (1955)
Show Items
Volume: 3 (1954)
Show Items
Volume: 2 (1953)
Show Items
Volume: 1 (1952)
Show Items
Volume: s1-31 (1951)
Show Items
Volume: s1-30 (1950)
Show Items
Volume: s1-29 (1949)
Show Items
Volume: s1-28 (1948)
Show Items
Volume: s1-27 (1947)
Show Items
Volume: s1-26 (1946)
Show Items
Volume: s1-25 (1945)
Show Items
Volume: s1-24 (1944)
Show Items
Volume: s1-23 (1943)
Show Items
Volume: s1-22 (1942)
Show Items
Volume: s1-21 (1941)
Show Items
Volume: s1-20 (1940)
Show Items
Volume: s1-19 (1939)
Show Items
Volume: s1-18 (1938)
Show Items
Volume: s1-17 (1937)
Show Items
Volume: s1-16 (1936)
Show Items
Volume: s1-15 (1935)
Show Items
Volume: s1-14 (1934)
Show Items
Volume: s1-13 (1933)
Show Items
Volume: s1-12 (1932)
Show Items
Volume: s1-11 (1931)
Show Items
Volume: s1-10 (1930)
Show Items
Volume: s1-9 (1929)
Show Items
Volume: s1-8 (1928)
Show Items
Volume: s1-7 (1927)
Show Items
Volume: s1-6 (1926)
Show Items
Volume: s1-5 (1925)
Show Items
Volume: s1-4 (1924)
Show Items
Volume: s1-3 (1923)
Show Items
Volume: s1-2 (1922)
Show Items
Volume: s1-1 (1921)
Show Items
Past two years Past Year Past 30 Days
Abstract Views 2757 1194 41
Full Text Views 115 28 3
PDF Downloads 126 41 5
 
 
 
 
Affiliate Membership Banner
 
 
Research for Health Information Banner
 
 
CLOCKSS
 
 
 
Society Publishers Coalition Banner
Save