Cover The American Journal of Tropical Medicine and Hygiene
The American Journal of Tropical Medicine and Hygiene
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0002-9637
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Quinine Loading Dose in Cerebral Malaria

Nicholas J. White, Sornchai Looareesuwan, David A. Warrell, Mary J. Warrell, Pornthep Chanthavanich, Danai Bunnag, and Tranakchit Harinasuta
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  • Faculty of Tropical Medicine, Mahidol University, Tropical Medicine Unit, Nuffield Department of Clinical Medicine, University of Oxford, Department of Tropical Medicine, Liverpool School of Tropical Medicine, 42016 Rajvithi Road, Bangkok 4, Thailand
DOI:
https://doi.org/10.4269/ajtmh.1983.32.1
Volume/Issue:
Volume 32: Issue 1
Page(s):
1–5
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In cerebral malaria, the use of currently recommended doses of intravenous quinine may result in subtherapeutic plasma concentrations during the critical first 24 hours of treatment. A loading dose of quinine (20 mg/kg quinine dihydrochloride, equivalent to 16.7 mg/kg base, infused over 4 hours) proved a rapid and safe method of achieving plasma concentrations above the high minimum inhibitory concentrations for Plasmodium falciparum prevalent in Eastern Thailand.
Copyright:
Copyright © 1983 The American Society of Tropical Medicine and Hygiene 1983
Accepted:
16 Jun 1982
|
Published Online:
Jan 1983
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