Ten strains of Aedes polynesiensis were infected with subperiodic Brugia malayi and Brugia pahangi. Susceptibility to B. malayi ranged from 92.1–100%, and susceptibility to B. pahangi from 97.5–100%. Further analysis showed significant differences in the numbers of third-stage larvae both between parasites and between strains within parasites. Because of the high levels of susceptibility, it appears that Ae. polynesiensis provides an even better laboratory model for vector-parasite studies than the strains of Ae. aegypti currently used.