Malaria and Erythrocyte Glucose-6-Phosphate Dehydrogenase Variants in West Africa

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  • Bernhard-Nocht-Institut für Schiffs- und Tropenkrankheiten, Department of Medicine, Department of Statistics, University of Erlangen, International Institute of Biophysics and Genetics, Hamburg, Germany

In a clinical study, 702 Nigerian children aged 1–6 years were examined for malaria. Comparison of morbidity rates and parasitemia of patients with different glucose-6-phosphate dehydrogenase (G6PD) status provided evidence that in heterozygous females the gene for G6PD deficiency (GdA-/GdB) confers an advantage against malaria.