Oxolinic Acid for the Treatment of Chronic Gastrointestinal Shigella Carriers

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  • Departments of Medicine and Microbiology, Medical College of Ohio, Toledo, Ohio 43699

Two patients were long-term gastrointestinal carriers of Shigella flexneri for 23 mo and 6 mo, respectively. Neither patient responded to oral antibiotics, despite in vitro sensitivity of the bacteria to the antibiotics administered. Oral oxolinic acid produced immediate cessation of the carrier state in both patients, with resolution of minor but persistent physical complaints.