A Precipitin Test for the Diagnosis of Human Abdominal Angiostrongyliasis

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  • Central America Research Station, Bureau of Tropical Diseases, Center for Disease Control, Public Health Service, U.S. Department of Health, Education, and Welfare, San Salvador, El Salvador

A precipitin reaction was observed when sera of cotton rats infected either naturally or experimentally with Angiostrongylus costaricensis were tested by gel double-diffusion against sera obtained from three biopsy-confirmed human cases of A. costaricensis. With immunoelectrophoresis, the antigen was demonstrated in the serum of infected rats. The antibody in the human serum was mostly of the IgG type. No cross reactions were seen with sera from individuals infected with the common intestinal helminths, or individuals serologically positive for Toxocara, A. cantonensis, Chagas' disease, amebiasis, leishmaniasis, toxoplasmosis, or syphilis.