The Host Antigen Phenomenon in Experimental Murine Schistosomiasis

III. Destruction of Parasites Transferred from Mice to Hamsters

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  • Department of Tropical Public Health, Harvard School of Public Health, 665 Huntington Avenue, Boston, Massachusetts 02115

The surgical transfer of 23- to 28-day-old Schistosoma mansoni from donor mice to the mesenteric vessels of outbred hamsters is followed by recovery of 70% of the transferred trematodes 30 days later. Prior immunization of hamsters with mouse erythrocytes results in anti-mouse erythrocyte antibody titers of >1:4,096 and death of 98% of the parasites. Destruction is correlated with evidence of the presence of mouse antigenic determinants on the surfaces of schistosomes from donor mice.

Author Notes

Present address: Tulane University School of Medicine, New Orleans, Louisiana 70112.

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